Int. J. Mol. Sci. 2015, 16(4), 8070-8101; doi:10.3390/ijms16048070
Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
1
Departament de FisicoquÃmica; Facultat de Farmà cia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
2
Departament de Farmà cia i Tecnologia Farmacèutica, Facultat de Farmà cia, Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
3
Departament de Fisiologia, Facultat de Farmà cia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: O. Thompson Mefford
Received: 4 March 2015 / Revised: 27 March 2015 / Accepted: 3 April 2015 / Published: 10 April 2015
(This article belongs to the Special Issue Magnetic Nanoparticles 2015)
Abstract
In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release. View Full-TextKeywords:
magnetic nanoparticles; magnetoliposomes; liposomes; gels; nanotechnology; controlled release; chemotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style
Estelrich, J.; Escribano, E.; Queralt, J.; Busquets, M.A. Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery. Int. J. Mol. Sci. 2015, 16, 8070-8101.
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