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Int. J. Mol. Sci. 2015, 16(4), 8070-8101; doi:10.3390/ijms16048070

Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery

1
Departament de Fisicoquímica; Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
2
Departament de Farmàcia i Tecnologia Farmacèutica, Facultat de Farmàcia, Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
3
Departament de Fisiologia, Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: O. Thompson Mefford
Received: 4 March 2015 / Revised: 27 March 2015 / Accepted: 3 April 2015 / Published: 10 April 2015
(This article belongs to the Special Issue Magnetic Nanoparticles 2015)
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Abstract

In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release. View Full-Text
Keywords: magnetic nanoparticles; magnetoliposomes; liposomes; gels; nanotechnology; controlled release; chemotherapy magnetic nanoparticles; magnetoliposomes; liposomes; gels; nanotechnology; controlled release; chemotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Estelrich, J.; Escribano, E.; Queralt, J.; Busquets, M.A. Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery. Int. J. Mol. Sci. 2015, 16, 8070-8101.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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