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Int. J. Mol. Sci. 2015, 16(4), 6818-6830; doi:10.3390/ijms16046818

Nano SiO2 and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology

1,2,†
,
3,†
,
2
,
4,5
,
2,4,* and 1,3,*
1
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China
2
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
3
Cancer Research Institute, Central South University, Changsha 410078, China
4
Orthopedic Biomedical Materials Institute, Central South University, Changsha 410083, China
5
Department of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha 410011, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 28 December 2014 / Accepted: 18 March 2015 / Published: 25 March 2015
(This article belongs to the Section Biomaterial Sciences)
View Full-Text   |   Download PDF [5150 KB, uploaded 25 March 2015]   |  

Abstract

Nano SiO2 and MgO particles were incorporated into β-tricalcium phosphate (β-TCP) scaffolds to improve the mechanical and biological properties. The porous cylindrical β-TCP scaffolds doped with 0.5 wt % SiO2, 1.0 wt % MgO, 0.5 wt % SiO2 + 1.0 wt % MgO were fabricated via selective laser sintering respectively and undoped β-TCP scaffold was also prepared as control. The phase composition and mechanical strength of the scaffolds were evaluated. X-ray diffraction analysis indicated that the phase transformation from β-TCP to α-TCP was inhibited after the addition of MgO. The compressive strength of scaffold was improved from 3.12 ± 0.36 MPa (β-TCP) to 5.74 ± 0.62 MPa (β-TCP/SiO2), 9.02 ± 0.55 MPa (β-TCP/MgO) and 10.43 ± 0.28 MPa (β-TCP/SiO2/MgO), respectively. The weight loss and apatite-forming ability of the scaffolds were evaluated by soaking them in simulated body fluid. The results demonstrated that both SiO2 and MgO dopings slowed down the degradation rate and improved the bioactivity of β-TCP scaffolds. In vitro cell culture studies indicated that SiO2 and MgO dopings facilitated cell attachment and proliferation. Combined addition of SiO2 and MgO were found optimal in enhancing both the mechanical and biological properties of β-TCP scaffold. View Full-Text
Keywords: β-tricalcium phosphate; SiO2; MgO; selective laser sintering; scaffolds β-tricalcium phosphate; SiO2; MgO; selective laser sintering; scaffolds
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Gao, C.; Wei, P.; Feng, P.; Xiao, T.; Shuai, C.; Peng, S. Nano SiO2 and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology. Int. J. Mol. Sci. 2015, 16, 6818-6830.

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