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Int. J. Mol. Sci. 2015, 16(3), 6251-6265; doi:10.3390/ijms16036251

Prediction of Long-Term Treatment Response to Selective Serotonin Reuptake Inhibitors (SSRIs) Using Scalp and Source Loudness Dependence of Auditory Evoked Potentials (LDAEP) Analysis in Patients with Major Depressive Disorder

1
Department of Psychiatry, Seoul Eunpyeong Hospital, 90, Baengnyeonsan-ro, Eunpyeong-gu, Seoul 122-913, Korea
2
Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, 2240, Daehwa-dong, Ilsanseo-gu, Goyang 411-706, Korea
3
Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang 411-706, Korea
4
Department of Biomedical Engineering, Hanyang University, Seoul 133-791, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Cesar Borlongan
Received: 3 December 2014 / Revised: 27 February 2015 / Accepted: 12 March 2015 / Published: 18 March 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [872 KB, uploaded 18 March 2015]   |  

Abstract

Background: Animal and clinical studies have demonstrated that the loudness dependence of auditory evoked potentials (LDAEP) is inversely related to central serotonergic activity, with a high LDAEP reflecting weak serotonergic neurotransmission and vice versa, though the findings in humans have been less consistent. In addition, a high pretreatment LDAEP appears to predict a favorable response to antidepressant treatments that augment the actions of serotonin. The aim of this study was to test whether the baseline LDAEP is correlated with response to long-term maintenance treatment in patients with major depressive disorder (MDD). Methods: Scalp N1, P2 and N1/P2 LDAEP and standardized low resolution brain electromagnetic tomography-localized N1, P2, and N1/P2 LDAEP were evaluated in 41 MDD patients before and after they received antidepressant treatment (escitalopram (n = 32, 10.0 ± 4.0 mg/day), sertraline (n = 7, 78.6 ± 26.7 mg/day), and paroxetine controlled-release formulation (n = 2, 18.8 ± 8.8 mg/day)) for more than 12 weeks. A treatment response was defined as a reduction in the Beck Depression Inventory (BDI) score of >50% between baseline and follow-up. Results: The responders had higher baseline scalp P2 and N1/P2 LDAEP than nonresponders (p = 0.017; p = 0.036). In addition, changes in total BDI score between baseline and follow-up were larger in subjects with a high baseline N1/P2 LDAEP than those with a low baseline N1/P2 LDAEP (p = 0.009). There were significantly more responders in the high-LDAEP group than in the low-LDAEP group (p = 0.041). Conclusions: The findings of this study reveal that a high baseline LDAEP is associated with a clinical response to long-term antidepressant treatment. View Full-Text
Keywords: antidepressants; loudness dependence of auditory evoked potentials (LDAEP); standardized low resolution brain electromagnetic tomography (sLORETA); major depressive disorder; response; serotonin antidepressants; loudness dependence of auditory evoked potentials (LDAEP); standardized low resolution brain electromagnetic tomography (sLORETA); major depressive disorder; response; serotonin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, B.-H.; Park, Y.-M.; Lee, S.-H.; Shim, M. Prediction of Long-Term Treatment Response to Selective Serotonin Reuptake Inhibitors (SSRIs) Using Scalp and Source Loudness Dependence of Auditory Evoked Potentials (LDAEP) Analysis in Patients with Major Depressive Disorder. Int. J. Mol. Sci. 2015, 16, 6251-6265.

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