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Int. J. Mol. Sci. 2015, 16(3), 6140-6152; doi:10.3390/ijms16036140

Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi

1
Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan
2
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Vladimír Křen
Received: 27 February 2015 / Revised: 9 March 2015 / Accepted: 11 March 2015 / Published: 17 March 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1776 KB, uploaded 17 March 2015]   |  

Abstract

Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structures of 15 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC50 values of 2.0 and 3.0 μM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC50 values of 25.0 μg/mL. View Full-Text
Keywords: polyoxygenated cembranoids; Sarcophyton ehrenbergi; cytotoxicity; HCMV (human cytomegalovirus) polyoxygenated cembranoids; Sarcophyton ehrenbergi; cytotoxicity; HCMV (human cytomegalovirus)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cheng, S.-Y.; Wang, S.-K.; Hsieh, M.-K.; Duh, C.-Y. Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi. Int. J. Mol. Sci. 2015, 16, 6140-6152.

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