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Int. J. Mol. Sci. 2015, 16(3), 4731-4743; doi:10.3390/ijms16034731

Discovery of a Potent Anti-Yeast Triterpenoid Saponin, Clematoside-S from Urena lobata L.

1
Rice Research Institute, Sichuan Agricultural University, Wenjiang 611130, China
2
College of Life Science, Sichuan Normal University, Chengdu 610101, China
3
College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu 610065, China
4
West China School of Public Health, Sichuan University, Chengdu 610041, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 16 December 2014 / Revised: 8 February 2015 / Accepted: 16 February 2015 / Published: 2 March 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [722 KB, uploaded 2 March 2015]   |  

Abstract

Urena lobata has been used as a traditional medicinal plant in India and China. In this study, we investigated the antimicrobial activity and isolated the active compound from the leaves of U. lobata. The 80% ethanol extract from U. lobata leaves showed an effective anti-yeast activity against Saccharomyces cerevisiae (S. cerevisiae) strains. Using a combination of chromatographic methods, (−)-trachelogenin (1) and clematoside-S (2) were isolated from this plant for the first time, and their chemical structure was identified by mass spectrometry (MS) and extensive nuclear magnetic resonance (NMR) data analysis. In addition, 1 was found to be inactive against all of the test microorganisms in the antimicrobial assay, whereas 2 exhibits a specific anti-yeast activity against S. cerevisiae strains with diameter of inhibition zones in the range from 11 to 20 mm. Furthermore, the MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values of 2 against S. cerevisiae strains were detected to be in the ranges of 0.61 to 9.8 μg/mL and 2.42 to 9.8 μg/mL, respectively. This is the first report of 2 with a specific anti-yeast activity. The above result suggests the potential application of U. lobata to be used as a natural anti-yeast agent in food preservation. View Full-Text
Keywords: Urena lobata; triterpene saponin; clematoside-S; anti-yeast activity Urena lobata; triterpene saponin; clematoside-S; anti-yeast activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gao, X.-L.; Liao, Y.; Wang, J.; Liu, X.-Y.; Zhong, K.; Huang, Y.-N.; Gao, H.; Gao, B.; Xu, Z.-J. Discovery of a Potent Anti-Yeast Triterpenoid Saponin, Clematoside-S from Urena lobata L.. Int. J. Mol. Sci. 2015, 16, 4731-4743.

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