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Int. J. Mol. Sci. 2015, 16(2), 4095-4120; doi:10.3390/ijms16024095

The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan
Division of Radiation Oncology, Taipei City Hospital RenAi Branch, Taipei 106, Taiwan
Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Guillermo T. Sáez
Received: 22 December 2014 / Revised: 26 January 2015 / Accepted: 9 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases 2014)
View Full-Text   |   Download PDF [1768 KB, uploaded 13 February 2015]   |  


The actin depolymerizing factor (ADF)/cofilin protein family is essential for actin dynamics, cell division, chemotaxis and tumor metastasis. Cofilin-1 (CFL-1) is a primary non-muscle isoform of the ADF/cofilin protein family accelerating the actin filamental turnover in vitro and in vivo. In response to environmental stimulation, CFL-1 enters the nucleus to regulate the actin dynamics. Although the purpose of this cytoplasm-nucleus transition remains unclear, it is speculated that the interaction between CFL-1 and DNA may influence various biological responses, including DNA damage repair. In this review, we will discuss the possible involvement of CFL-1 in DNA damage responses (DDR) induced by ionizing radiation (IR), and the implications for cancer radiotherapy. View Full-Text
Keywords: actin cytoskeleton; ADF/cofilin; radiosensitivity; DDR; radiotherapy actin cytoskeleton; ADF/cofilin; radiosensitivity; DDR; radiotherapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chang, C.-Y.; Leu, J.-D.; Lee, Y.-J. The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer. Int. J. Mol. Sci. 2015, 16, 4095-4120.

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