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Int. J. Mol. Sci. 2015, 16(2), 4083-4094; doi:10.3390/ijms16024083

Autophagy as a Regulatory Component of Erythropoiesis

1
State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China
2
Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
3
Laboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA
4
College of Life Science, Zhengzhou University, Zhengzhou 450001, China
*
Author to whom correspondence should be addressed.
Academic Editors: Jaime M. Ross and Giuseppe Coppotelli
Received: 8 January 2015 / Revised: 5 February 2015 / Accepted: 9 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases)
View Full-Text   |   Download PDF [793 KB, uploaded 13 February 2015]   |  

Abstract

Autophagy is a process that leads to the degradation of unnecessary or dysfunctional cellular components and long-lived protein aggregates. Erythropoiesis is a branch of hematopoietic differentiation by which mature red blood cells (RBCs) are generated from multi-potential hematopoietic stem cells (HSCs). Autophagy plays a critical role in the elimination of mitochondria, ribosomes and other organelles during erythroid terminal differentiation. Here, the modulators of autophagy that regulate erythroid differentiation were summarized, including autophagy-related (Atg) genes, the B-cell lymphoma 2 (Bcl-2) family member Bcl-2/adenovirus E1B 19 kDa interacting protein 3-like (Nix/Binp3L), transcription factors globin transcription factor 1 (GATA1) and forkhead box O3 (FoxO3), intermediary factor KRAB-associated protein1 (KAP1), and other modulators, such as focal adhesion kinase family-interacting protein of 200-kDa (FIP200), Ca2+ and 15-lipoxygenase. Understanding the modulators of autophagy in erythropoiesis will benefit the autophagy research field and facilitate the prevention and treatment of autophagy-related red blood cell disorders. View Full-Text
Keywords: autophagy; modulators; erythropoiesis autophagy; modulators; erythropoiesis
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Zhang, J.; Wu, K.; Xiao, X.; Liao, J.; Hu, Q.; Chen, H.; Liu, J.; An, X. Autophagy as a Regulatory Component of Erythropoiesis. Int. J. Mol. Sci. 2015, 16, 4083-4094.

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