Autophagy as a Regulatory Component of Erythropoiesis
AbstractAutophagy is a process that leads to the degradation of unnecessary or dysfunctional cellular components and long-lived protein aggregates. Erythropoiesis is a branch of hematopoietic differentiation by which mature red blood cells (RBCs) are generated from multi-potential hematopoietic stem cells (HSCs). Autophagy plays a critical role in the elimination of mitochondria, ribosomes and other organelles during erythroid terminal differentiation. Here, the modulators of autophagy that regulate erythroid differentiation were summarized, including autophagy-related (Atg) genes, the B-cell lymphoma 2 (Bcl-2) family member Bcl-2/adenovirus E1B 19 kDa interacting protein 3-like (Nix/Binp3L), transcription factors globin transcription factor 1 (GATA1) and forkhead box O3 (FoxO3), intermediary factor KRAB-associated protein1 (KAP1), and other modulators, such as focal adhesion kinase family-interacting protein of 200-kDa (FIP200), Ca2+ and 15-lipoxygenase. Understanding the modulators of autophagy in erythropoiesis will benefit the autophagy research field and facilitate the prevention and treatment of autophagy-related red blood cell disorders. View Full-Text
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Zhang, J.; Wu, K.; Xiao, X.; Liao, J.; Hu, Q.; Chen, H.; Liu, J.; An, X. Autophagy as a Regulatory Component of Erythropoiesis. Int. J. Mol. Sci. 2015, 16, 4083-4094.
Zhang J, Wu K, Xiao X, Liao J, Hu Q, Chen H, Liu J, An X. Autophagy as a Regulatory Component of Erythropoiesis. International Journal of Molecular Sciences. 2015; 16(2):4083-4094.Chicago/Turabian Style
Zhang, Jieying; Wu, Kunlu; Xiao, Xiaojuan; Liao, Jiling; Hu, Qikang; Chen, Huiyong; Liu, Jing; An, Xiuli. 2015. "Autophagy as a Regulatory Component of Erythropoiesis." Int. J. Mol. Sci. 16, no. 2: 4083-4094.