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Int. J. Mol. Sci. 2015, 16(2), 2971-3016; doi:10.3390/ijms16022971

Effects of Atmospheric Pressure Plasmas on Isolated and Cellular DNA—A Review

1
Radiation Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA
2
Department of Environmental and Occupational Health, School of Public Health, Texas A&M University, 1266 TAMU, College Station, TX 77843, USA
3
Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA
4
Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Guillermo T. Sáez
Received: 7 November 2014 / Revised: 14 January 2015 / Accepted: 15 January 2015 / Published: 29 January 2015
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases 2014)
View Full-Text   |   Download PDF [3217 KB, uploaded 29 January 2015]   |  

Abstract

Atmospheric Pressure Plasma (APP) is being used widely in a variety of biomedical applications. Extensive research in the field of plasma medicine has shown the induction of DNA damage by APP in a dose-dependent manner in both prokaryotic and eukaryotic systems. Recent evidence suggests that APP-induced DNA damage shows potential benefits in many applications, such as sterilization and cancer therapy. However, in several other applications, such as wound healing and dentistry, DNA damage can be detrimental. This review reports on the extensive investigations devoted to APP interactions with DNA, with an emphasis on the critical role of reactive species in plasma-induced damage to DNA. The review consists of three main sections dedicated to fundamental knowledge of the interactions of reactive oxygen species (ROS)/reactive nitrogen species (RNS) with DNA and its components, as well as the effects of APP on isolated and cellular DNA in prokaryotes and eukaryotes. View Full-Text
Keywords: plasma medicine; atmospheric pressure plasma; DNA; ROS/RNS; ATM/ATR plasma medicine; atmospheric pressure plasma; DNA; ROS/RNS; ATM/ATR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Arjunan, K.P.; Sharma, V.K.; Ptasinska, S. Effects of Atmospheric Pressure Plasmas on Isolated and Cellular DNA—A Review. Int. J. Mol. Sci. 2015, 16, 2971-3016.

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