Special Issue "Pre-mRNA Splicing"
Deadline for manuscript submissions: closed (20 December 2014)
Prof. Akila Mayeda
Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
Interests: pre-mRNA splicing; mechanism of splicing; regulation of splicing; aberrant splicing in diseases
In eukaryotes, most gene transcripts (pre-mRNAs) are interrupted by intervening sequences termed “introns”, which are precisely removed by a process called splicing. This process is essential since spliced mRNAs serve as the templates of proteins. The higher eukaryotes have been evolved to gain more and more introns of increasing size; this evolution enables complexity and flexibility in the splicing process, and produces alternative splicing. In humans, alternative splicing is a successful, major strategy for expressing a full proteome of at least 120,000 proteins from an unexpectedly small genome of, at most, 20,500 genes. Recent studies have revealed that over 90% of human genes undergo alternative splicing; over 60% of such splicing processes are tissue-specifically regulated. Regulations in the splicing process are definitely crucial for a wide variety of biological and physiological phenomena. The process is therefore highly discriminatory and faithful, and mis-regulation in this process causes disorders in cell functions, which often leads to severe clinical consequences.
This special issue of the International Journal of Molecular Sciences (IJMS), “Pre-mRNA Splicing,” will cover a broad range of basic and applied studies of pre-mRNA splicing. Topics include, but are not limited to: the mechanism and regulation of constitutive and alternative splicing, pre-mRNA–protein interactions, hnRNP/mRNP assembly and functions, global analyses and evolutional studies of pre-mRNAs and splicing factors, and pre-mRNA processing in development and diseases.
Prof. Akila Mayeda
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- constitutive splicing
- alternative splicing
- aberrant splicing
- splicing mechanism
- splicing regulation
- splicing factors
- splicing enhancers
- splicing silencers
- SR proteins