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Int. J. Mol. Sci. 2015, 16(2), 3377-3390; doi:10.3390/ijms16023377

Predicted Trans-Acting siRNAs in the Human Brain

1
The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
2
College of Horticulture, Jinling Institute of Technology, Nanjing 210038, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 27 October 2014 / Revised: 10 December 2014 / Accepted: 25 December 2014 / Published: 3 February 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [755 KB, uploaded 3 February 2015]   |  

Abstract

Endogenous small non-coding RNAs play pivotal roles in regulating gene expression in eukaryotes. Many studies have investigated the function and molecular mechanism of microRNAs in the development and disease of various organisms via mRNA repression of protein-coding genes. Recent findings indicate microRNAs might trigger the generation of trans-acting small interfering RNAs (ta-siRNAs). The interaction among different types of small RNA molecules reveals an even more complicated and elaborate pattern of RNA regulation during gene expression than previously thought. We developed a method for mining ta-siRNA sequences and evaluated the performance of our novel method using data from Arabidopsis thaliana. Additionally, using small RNA and degradome data for the human brain, we identified 155 small RNAs that satisfied ta-siRNA characteristics. The DRAXIN and ATCAY genes, which are preferentially expressed in the human brain, were predicted to be the targets of 12 potential ta-siRNAs. View Full-Text
Keywords: trans-acting small interfering RNA; microRNA; human brain; cascade regulation trans-acting small interfering RNA; microRNA; human brain; cascade regulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, X.; Zhang, G.; Zhang, C.; Wang, J. Predicted Trans-Acting siRNAs in the Human Brain. Int. J. Mol. Sci. 2015, 16, 3377-3390.

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