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Int. J. Mol. Sci. 2015, 16(2), 3350-3376; doi:10.3390/ijms16023350

Dietary Polyphenols in Prevention and Treatment of Prostate Cancer

1
Department of Food Science, University of Wisconsin, Madison, WI 53706, USA
2
Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Sanjay K. Srivastava
Received: 9 January 2015 / Revised: 21 January 2015 / Accepted: 26 January 2015 / Published: 3 February 2015
(This article belongs to the Special Issue Bioactive Phytochemicals in Functional Foods for Cancer Prevention)
View Full-Text   |   Download PDF [1969 KB, uploaded 3 February 2015]   |  

Abstract

Prostate cancer is the most prevalent disease affecting males in many Western countries, with an estimated 29,480 deaths in 2014 in the US alone. Incidence rates for prostate cancer deaths have been decreasing since the early 1990s in men of all races/ethnicities, though they remain about 60% higher in African Americans than in any other group. The relationship between dietary polyphenols and the prevention of prostate cancer has been examined previously. Although results are sometimes inconsistent and variable, there is a general agreement that polyphenols hold great promise for the future management of prostate cancer. Various dietary components, including polyphenols, have been shown to possess anti-cancer properties. Generally considered as non-toxic, dietary polyphenols act as key modulators of signaling pathways and are therefore considered ideal chemopreventive agents. Besides possessing various anti-tumor properties, dietary polyphenols also contribute to epigenetic changes associated with the fate of cancer cells and have emerged as potential drugs for therapeutic intervention. Polyphenols have also been shown to affect post-translational modifications and microRNA expressions. This article provides a systematic review of the health benefits of selected dietary polyphenols in prostate cancer, especially focusing on the subclasses of polyphenols, which have a great effect on disease prevention and treatment. View Full-Text
Keywords: dietary polyphenols; prostate cancer; chemoprevention; phenolic acid; flavonoids; stilbenes; curcuminoids dietary polyphenols; prostate cancer; chemoprevention; phenolic acid; flavonoids; stilbenes; curcuminoids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lall, R.K.; Syed, D.N.; Adhami, V.M.; Khan, M.I.; Mukhtar, H. Dietary Polyphenols in Prevention and Treatment of Prostate Cancer. Int. J. Mol. Sci. 2015, 16, 3350-3376.

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