Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa
AbstractA known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds. View Full-Text
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Chen, W.-F.; Yin, C.-T.; Cheng, C.-H.; Lu, M.-C.; Fang, L.-S.; Wang, W.-H.; Wen, Z.-H.; Chen, J.-J.; Wu, Y.-C.; Sung, P.-J. Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa. Int. J. Mol. Sci. 2015, 16, 3298-3306.
Chen W-F, Yin C-T, Cheng C-H, Lu M-C, Fang L-S, Wang W-H, Wen Z-H, Chen J-J, Wu Y-C, Sung P-J. Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa. International Journal of Molecular Sciences. 2015; 16(2):3298-3306.Chicago/Turabian Style
Chen, Wu-Fu; Yin, Chen-Ting; Cheng, Ching-Hsiao; Lu, Mei-Chin; Fang, Lee-Shing; Wang, Wei-Hsien; Wen, Zhi-Hong; Chen, Jih-Jung; Wu, Yang-Chang; Sung, Ping-Jyun. 2015. "Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa." Int. J. Mol. Sci. 16, no. 2: 3298-3306.