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Int. J. Mol. Sci. 2015, 16(2), 2913-2941; doi:10.3390/ijms16022913

Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae

1
Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China
2
System Biology Lab, University of Florida, Gainesville, FL 32608, USA
3
Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32608, USA
4
School of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, China
5
Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling 712100, China
6
Lab of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Vladimír Křen
Received: 13 November 2014 / Accepted: 22 January 2015 / Published: 28 January 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [4407 KB, uploaded 6 February 2015]   |  

Abstract

Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid arthritis pathway and NF-κB signaling pathway. All these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations. View Full-Text
Keywords: systems pharmacology; herbal medicine; anti-inflammation; Folium Eriobotryae systems pharmacology; herbal medicine; anti-inflammation; Folium Eriobotryae
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MDPI and ACS Style

Zhang, J.; Li, Y.; Chen, S.-S.; Zhang, L.; Wang, J.; Yang, Y.; Zhang, S.; Pan, Y.; Wang, Y.; Yang, L. Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae. Int. J. Mol. Sci. 2015, 16, 2913-2941.

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