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Int. J. Mol. Sci. 2015, 16(2), 2879-2892; doi:10.3390/ijms16022879

BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease

Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan
These authors are equally contributed to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Kurt A. Jellinger
Received: 29 October 2014 / Revised: 20 November 2014 / Accepted: 20 January 2015 / Published: 28 January 2015
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases 2014)
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Abstract

Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field. View Full-Text
Keywords: BRCA1; p53; Alzheimer’s disease; tumor suppressor; DNA repair; cell signaling; dietary supplementation BRCA1; p53; Alzheimer’s disease; tumor suppressor; DNA repair; cell signaling; dietary supplementation
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Nakanishi, A.; Minami, A.; Kitagishi, Y.; Ogura, Y.; Matsuda, S. BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease. Int. J. Mol. Sci. 2015, 16, 2879-2892.

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