Next Article in Journal
The Influence of AHI1 Variants on the Diagnosis and Treatment Outcome in Schizophrenia
Previous Article in Journal
Promoter Hypermethylation of Tumour Suppressor Genes as Potential Biomarkers in Colorectal Cancer
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(2), 2497-2516; doi:10.3390/ijms16022497

Chemical Constituents Analysis and Antidiabetic Activity Validation of Four Fern Species from Taiwan

1
College of Pharmacy, School of Pharmacy, Taipei Medical University, 250 Wuxing St., Taipei 110, Taiwan
2
Graduate Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, 250 Wuxing St., Taipei 110, Taiwan
3
Department of Life Science, National Taiwan Normal University, No. 162, Sec. 1, Heping E. Rd., Taipei 106, Taiwan
4
Department of Physiology and Biophysics, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Rd., Taipei 114, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 25 November 2014 / Accepted: 13 January 2015 / Published: 22 January 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [2704 KB, uploaded 22 January 2015]   |  

Abstract

Pterosins are abundant in ferns, and pterosin A was considered a novel activator of adenosine monophosphate-activated protein kinase, which is crucial for regulating blood glucose homeostasis. However, the distribution of pterosins in different species of ferns from various places in Taiwan is currently unclear. To address this question, the distribution of pterosins, glucose-uptake efficiency, and protective effects of pterosin A on β-cells were examined. Our results showed that three novel compounds, 13-chloro-spelosin 3-O-β-d-glucopyranoside (1), (3R)-Pterosin D 3-O-β-d-(3'-p-coumaroyl)-glucopyranoside (2), and (2R,3R)-Pterosin L 3-O-β-d-(3'-p-coumaroyl)-glucopyranoside (3), were isolated for the first time from four fern species (Ceratopteris thalictroides, Hypolepis punctata, Nephrolepis multiflora, and Pteridium revolutum) along with 27 known compounds. We also examined the distribution of these pterosin compounds in the mentioned fern species (except N. multiflora). Although all pterosin analogs exhibited the same effects in glucose uptake assays, pterosin A prevented cell death and reduced reactive oxygen species (ROS) production. This paper is the first report to provide new insights into the distribution of pterosins in ferns from Taiwan. The potential anti-diabetic activity of these novel phytocompounds warrants further functional studies. View Full-Text
Keywords: pterosin; reactive oxygen species (ROS); rat pancreatic insulin-secreting (RINm5F) cells pterosin; reactive oxygen species (ROS); rat pancreatic insulin-secreting (RINm5F) cells
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, C.-Y.; Chiu, F.-Y.; Lin, Y.; Huang, W.-J.; Hsieh, P.-S.; Hsu, F.-L. Chemical Constituents Analysis and Antidiabetic Activity Validation of Four Fern Species from Taiwan. Int. J. Mol. Sci. 2015, 16, 2497-2516.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top