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Int. J. Mol. Sci. 2015, 16(2), 2458-2471; doi:10.3390/ijms16022458

Expression of the SIRT2 Gene and Its Relationship with Body Size Traits in Qinchuan Cattle (Bos taurus)

College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Institute of Soil and Water Conservation, Chinese Academy of Science and Ministry of Water Resource, Yangling 712100, China
National Beef Cattle Improvement Center of Northwest A&F University, Yangling 712100, China
These authors contributed equally to this study.
Author to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 10 October 2014 / Revised: 6 January 2015 / Accepted: 13 January 2015 / Published: 22 January 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1470 KB, uploaded 22 January 2015]   |  


Silent information regulator 2 (SIRT2) is a member of the sirtuin family of class III NAD (nicotinamide adenine dinucleotide)-dependent protein deacetylases and may regulate senescence, metabolism and apoptosis. The aims of this study were to investigate whether the SIRT2 gene could be used as a candidate gene in the breeding of Qinchuan cattle. Real-time polymerase chain reaction (RT-PCR) results showed that among all types of tissue that were analyzed, the highest mRNA expression levels of the gene were found in subcutaneous fat. DNA sequencing of 468 individual Qinchuan cattle identified two novel, single nucleotide polymorphisms (g.19501 C > T and g.19518 C > T) in the 3' untranslated region (3'UTR) of the SIRT2 gene. The frequencies of SNP g.19501 C > T and g.19518 C > T were in Hardy-Weinberg disequilibrium in all the samples (chi-square test, χ2 < χ0.052). An association analysis showed that the two loci were significantly correlated with some body size traits and the H2H2 (-CT-CT-) diplotypes performed better than other combinations. These results indicated that the variations in the SIRT2 gene and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding. View Full-Text
Keywords: SIRT2 gene; expression study; body size traits; Qinchuan cattle SIRT2 gene; expression study; body size traits; Qinchuan cattle

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Gui, L.-S.; Zhang, Y.-R.; Liu, G.-Y.; Zan, L.-S. Expression of the SIRT2 Gene and Its Relationship with Body Size Traits in Qinchuan Cattle (Bos taurus). Int. J. Mol. Sci. 2015, 16, 2458-2471.

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