Next Article in Journal
Exogenous Spermidine Alleviates Low Temperature Injury in Mung Bean (Vigna radiata L.) Seedlings by Modulating Ascorbate-Glutathione and Glyoxalase Pathway
Next Article in Special Issue
miR-9-5p, miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation, Differentiation, and Adhesion
Previous Article in Journal
Correction: Xiong, Z., et al. Different Roles of GRP78 on Cell Proliferation and Apoptosis in Cartilage Development. Int. J. Mol. Sci. 2015, 16, 21153–21176
Previous Article in Special Issue
miR-29a Participated in Nacre Formation and Immune Response by Targeting Y2R in Pinctada martensii
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(12), 30105-30116; doi:10.3390/ijms161226223

MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer’s Disease (AD)-Novel and Unique Pathological Features

1
Louisiana State University Neuroscience Center, LSU Health Sciences Center, New Orleans, LA 70112, USA
2
Department of Anatomy and Cell Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
3
Alchem Biotek, Toronto, ON M5S 1A8, Canada
4
Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
5
Department of Neurology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 7 December 2015 / Revised: 12 December 2015 / Accepted: 15 December 2015 / Published: 17 December 2015
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [864 KB, uploaded 17 December 2015]   |  

Abstract

Of the approximately ~2.65 × 103 mature microRNAs (miRNAs) so far identified in Homo sapiens, only a surprisingly small but select subset—about 35–40—are highly abundant in the human central nervous system (CNS). This fact alone underscores the extremely high selection pressure for the human CNS to utilize only specific ribonucleotide sequences contained within these single-stranded non-coding RNAs (ncRNAs) for productive miRNA–mRNA interactions and the down-regulation of gene expression. In this article we will: (i) consolidate some of our still evolving ideas concerning the role of miRNAs in the CNS in normal aging and in health, and in sporadic Alzheimer’s disease (AD) and related forms of chronic neurodegeneration; and (ii) highlight certain aspects of the most current work in this research field, with particular emphasis on the findings from our lab of a small pathogenic family of six inducible, pro-inflammatory, NF-κB-regulated miRNAs including miRNA-7, miRNA-9, miRNA-34a, miRNA-125b, miRNA-146a and miRNA-155. This group of six CNS-abundant miRNAs significantly up-regulated in sporadic AD are emerging as what appear to be key mechanistic contributors to the sporadic AD process and can explain much of the neuropathology of this common, age-related inflammatory neurodegeneration of the human CNS. View Full-Text
Keywords: Aβ42 peptide; age-related macular degeneration (AMD); amyloid clearance; heterogeneity of the disease process; inflammation; innate-immune response; microRNA (miRNA); miRNA-7; miRNA-9; miRNA-34a; miRNA-125b; miRNA-146a; miRNA-155; normal aging; prion disease; sporadic AD Aβ42 peptide; age-related macular degeneration (AMD); amyloid clearance; heterogeneity of the disease process; inflammation; innate-immune response; microRNA (miRNA); miRNA-7; miRNA-9; miRNA-34a; miRNA-125b; miRNA-146a; miRNA-155; normal aging; prion disease; sporadic AD
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhao, Y.; Pogue, A.I.; Lukiw, W.J. MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer’s Disease (AD)-Novel and Unique Pathological Features. Int. J. Mol. Sci. 2015, 16, 30105-30116.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top