Synthesis and Evaluation of Neuroprotective Selenoflavanones
AbstractThe physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments. View Full-Text
Share & Cite This Article
Choi, Y.-S.; Kim, D.-M.; Kim, Y.-J.; Yang, S.; Lee, K.-T.; Ryu, J.H.; Jeong, J.-H. Synthesis and Evaluation of Neuroprotective Selenoflavanones. Int. J. Mol. Sci. 2015, 16, 29574-29582.
Choi Y-S, Kim D-M, Kim Y-J, Yang S, Lee K-T, Ryu JH, Jeong J-H. Synthesis and Evaluation of Neuroprotective Selenoflavanones. International Journal of Molecular Sciences. 2015; 16(12):29574-29582.Chicago/Turabian Style
Choi, Yong-Sung; Kim, Dong-Myung; Kim, Yoon-Jung; Yang, Sai; Lee, Kyung-Tae; Ryu, Jong H.; Jeong, Jin-Hyun. 2015. "Synthesis and Evaluation of Neuroprotective Selenoflavanones." Int. J. Mol. Sci. 16, no. 12: 29574-29582.