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Int. J. Mol. Sci. 2015, 16(12), 29574-29582; doi:10.3390/ijms161226188

Synthesis and Evaluation of Neuroprotective Selenoflavanones

1
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea
2
Office of Research Affairs, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03720, Korea
3
College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02453, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Received: 1 November 2015 / Revised: 30 November 2015 / Accepted: 4 December 2015 / Published: 10 December 2015
(This article belongs to the Collection Neuroprotective Strategies)
View Full-Text   |   Download PDF [1239 KB, uploaded 10 December 2015]   |  

Abstract

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments. View Full-Text
Keywords: selenoflavanone; flavanone; selenium; neuroprotect; antioxidant; blood-brain barrier (BBB) selenoflavanone; flavanone; selenium; neuroprotect; antioxidant; blood-brain barrier (BBB)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Choi, Y.-S.; Kim, D.-M.; Kim, Y.-J.; Yang, S.; Lee, K.-T.; Ryu, J.H.; Jeong, J.-H. Synthesis and Evaluation of Neuroprotective Selenoflavanones. Int. J. Mol. Sci. 2015, 16, 29574-29582.

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