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Int. J. Mol. Sci. 2015, 16(10), 23784-23822; doi:10.3390/ijms161023784

Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems

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1
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
2
Hong Kong Baptist University Branch of State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University, Hong Kong, China
3
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410000, China
4
College of Biology, Hunan University, Changsha 410000, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 9 August 2015 / Revised: 16 September 2015 / Accepted: 21 September 2015 / Published: 9 October 2015
View Full-Text   |   Download PDF [2176 KB, uploaded 9 October 2015]   |  

Abstract

Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems. View Full-Text
Keywords: aptamer-functionalized targeted drug delivery systems; aptamer; SELEX; aptamer-small molecule conjugated systems; aptamer-nanomaterial conjugated systems aptamer-functionalized targeted drug delivery systems; aptamer; SELEX; aptamer-small molecule conjugated systems; aptamer-nanomaterial conjugated systems
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jiang, F.; Liu, B.; Lu, J.; Li, F.; Li, D.; Liang, C.; Dang, L.; Liu, J.; He, B.; Badshah, S.A.; Lu, C.; He, X.; Guo, B.; Zhang, X.-B.; Tan, W.; Lu, A.; Zhang, G. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems. Int. J. Mol. Sci. 2015, 16, 23784-23822.

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