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Int. J. Mol. Sci. 2015, 16(10), 23745-23759; doi:10.3390/ijms161023745

Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis

1,2,†,* , 2,3,†
and
1,2
1
Institute of Cardiology, School of Medicine, Jagiellonian University, 31-202 Cracow, Poland
2
John Paul II Hospital, 31-202 Cracow, Poland
3
Institute of Laboratory Medicine, Philipps-Universität Marburg, 35043 Marburg, Germany
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Emil Alexov
Received: 1 July 2015 / Revised: 28 August 2015 / Accepted: 31 August 2015 / Published: 9 October 2015
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
View Full-Text   |   Download PDF [727 KB, uploaded 9 October 2015]   |  

Abstract

Elevation in C-reactive protein (CRP) levels have been shown in patients with aortic valve stenosis (AS). Minor allele of the CRP gene (CRP) rs1205 C>T polymorphism has been associated with lower plasma CRP concentrations in cohorts of healthy and atherosclerotic patients. Considering the existing similarities between atherosclerosis and AS, we examined the effect of CRP rs1205 C>T polymorphism on the AS severity. Three hundred consecutive Caucasian patients diagnosed with AS were genotyped for the rs1205 C>T polymorphism using the TaqMan assay. Severity of the AS was assessed using transthoracic echocardiography. The degree of calcification was analyzed semi-quantitatively. Carriers of the rs1205 T allele were characterized by elevated serum CRP levels (2.53 (1.51–3.96) vs. 1.68 (0.98–2.90) mg/L, p < 0.001) and a higher proportion of the severe aortic valve calcification (70.4% vs. 55.1%, p = 0.01) compared with major homozygotes. The effect of CRP rs1205 polymorphism on CRP levels is opposite in AS-affected than in unaffected subjects, suggesting existence of a disease-specific molecular regulatory mechanism. Furthermore, rs1205 variant allele predisposes to larger aortic valve calcification, potentially being a novel genetic risk marker of disease progression. View Full-Text
Keywords: CRP; CRP rs1205 C>T polymorphism; aortic valve stenosis; calcification CRP; CRP rs1205 C>T polymorphism; aortic valve stenosis; calcification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wypasek, E.; Potaczek, D.P.; Undas, A. Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis. Int. J. Mol. Sci. 2015, 16, 23745-23759.

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