tRNAs as Antibiotic Targets
AbstractTransfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial “stringent response” mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed. View Full-Text
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Chopra, S.; Reader, J. tRNAs as Antibiotic Targets. Int. J. Mol. Sci. 2015, 16, 321-349.
Chopra S, Reader J. tRNAs as Antibiotic Targets. International Journal of Molecular Sciences. 2015; 16(1):321-349.Chicago/Turabian Style
Chopra, Shaileja; Reader, John. 2015. "tRNAs as Antibiotic Targets." Int. J. Mol. Sci. 16, no. 1: 321-349.