Next Article in Journal
Plasma Levels of Dimethylarginines in Preterm Very Low Birth Weight Neonates: Its Relation with Perinatal Factors and Short-Term Outcome
Next Article in Special Issue
Transgenic Plants as Low-Cost Platform for Chemotherapeutic Drugs Screening
Previous Article in Journal
From End to End: tRNA Editing at 5'- and 3'-Terminal Positions
Previous Article in Special Issue
Contribution of Chitinase A’s C-Terminal Vacuolar Sorting Determinant to the Study of Soluble Protein Compartmentation
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(1), 1-18; doi:10.3390/ijms16010001

Formins: Linking Cytoskeleton and Endomembranes in Plant Cells

1
Department of Experimental Plant Biology, Faculty of Sciences, Charles University, Viničná 5, 128 43 Prague 2, Czech Republic
2
Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Rozvojová 263, 165 02 Prague 6, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Gian-Pietro Di Sansebastiano
Received: 2 December 2014 / Accepted: 17 December 2014 / Published: 23 December 2014
(This article belongs to the Special Issue Plant Cell Compartmentation and Volume Control)
View Full-Text   |   Download PDF [4930 KB, uploaded 23 December 2014]   |  

Abstract

The cytoskeleton plays a central part in spatial organization of the plant cytoplasm, including the endomebrane system. However, the mechanisms involved are so far only partially understood. Formins (FH2 proteins), a family of evolutionarily conserved proteins sharing the FH2 domain whose dimer can nucleate actin, mediate the co-ordination between actin and microtubule cytoskeletons in multiple eukaryotic lineages including plants. Moreover, some plant formins contain transmembrane domains and participate in anchoring cytoskeletal structures to the plasmalemma, and possibly to other membranes. Direct or indirect membrane association is well documented even for some fungal and metazoan formins lacking membrane insertion motifs, and FH2 proteins have been shown to associate with endomembranes and modulate their dynamics in both fungi and metazoans. Here we summarize the available evidence suggesting that formins participate in membrane trafficking and endomembrane, especially ER, organization also in plants. We propose that, despite some methodological pitfalls inherent to in vivo studies based on (over)expression of truncated and/or tagged proteins, formins are beginning to emerge as candidates for the so far somewhat elusive link between the plant cytoskeleton and the endomembrane system. View Full-Text
Keywords: formin; actin; microtubules; endoplasmic reticulum; Golgi; fusion proteins; AtFH4; AtFH5; AtFH16 formin; actin; microtubules; endoplasmic reticulum; Golgi; fusion proteins; AtFH4; AtFH5; AtFH16
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cvrčková, F.; Oulehlová, D.; Žárský, V. Formins: Linking Cytoskeleton and Endomembranes in Plant Cells. Int. J. Mol. Sci. 2015, 16, 1-18.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top