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Int. J. Mol. Sci. 2014, 15(9), 16043-16056; doi:10.3390/ijms150916043

Environmental Factors, Toxicants and Systemic Lupus Erythematosus

1,2,* and 1,2
1
Division of Rheumatology, Department of Medicine, University Medicine Cluster, National University Health System, 1E Kent Ridge Road, Level 10, NUHS Tower Block 119228, Singapore
2
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
*
Author to whom correspondence should be addressed.
Received: 23 June 2014 / Revised: 1 August 2014 / Accepted: 27 August 2014 / Published: 11 September 2014
(This article belongs to the Special Issue Environmental Toxicants and Autoimmune Disease)
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Abstract

Systemic lupus erythematosus (SLE) is an immune-complex-mediated multi-systemic autoimmune condition of multifactorial etiology, which mainly affects young women. It is currently believed that the onset of SLE and lupus flares are triggered by various environmental factors in genetically susceptible individuals. Various environmental agents and toxicants, such as cigarette smoke, alcohol, occupationally- and non-occupationally-related chemicals, ultraviolet light, infections, sex hormones and certain medications and vaccines, have been implicated to induce SLE onset or flares in a number case series, case-control and population-based cohort studies and very few randomized controlled trials. Here, we will describe some of these recognized environmental lupus triggering and perpetuating factors and explain how these factors potentially bias the immune system towards autoimmunity through their interactions with genetic and epigenetic alterations. Further in-depth exploration of how potentially important environmental factors mechanistically interact with the immune system and the genome, which trigger the onset of SLE and lupus flares, will certainly be one of the plausible steps to prevent the onset and to decelerate the progress of the disease. View Full-Text
Keywords: environmental factors; toxicants; genetics; epigenetics; T-cells; systemic lupus erythematosus environmental factors; toxicants; genetics; epigenetics; T-cells; systemic lupus erythematosus
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Mak, A.; Tay, S.H. Environmental Factors, Toxicants and Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2014, 15, 16043-16056.

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