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Int. J. Mol. Sci. 2014, 15(9), 15981-15993; doi:10.3390/ijms150915981

Adsorption of Bisphenol A to a Carbon Nanotube Reduced Its Endocrine Disrupting Effect in Mice Male Offspring

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
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Received: 30 June 2014 / Revised: 1 September 2014 / Accepted: 2 September 2014 / Published: 10 September 2014
(This article belongs to the Special Issue Bioactive Nanoparticles 2014)
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Abstract

Soluble carbon nanotubes (CNTs) have shown promise as materials for adsorption of environmental contaminants such as Bisphenol A (BPA), due to the high adsorption capacity and strong desorption hysteresis of BPA on CNTs. The adsorption of BPA to CNTs may change the properties of both BPA and CNTs, and induce different toxicity to human and living systems from that of BPA and CNTs alone. Herein, we report that oral exposure of BPA/MWCNT–COOH (carboxylated multi-walled carbon nantubes) adduct to mice during gestation and lactation period decreased the male offspring reproductive toxicity compared with those induced by BPA alone. The adduct decreased malondialdehyde (MDA) level in testis and follicle-stimulating hormone (FSH) in serum, but increased the level of serum testosterone in male offspring in comparison to BPA alone. Our investigations broadened the knowledge of nanotoxicity and provided important information on the safe application of CNTs. View Full-Text
Keywords: carbon nanotubes (CNTs); Bisphenol A (BPA); contaminants adsorption; environmental endocrine disrupting effect; reproductive toxicity carbon nanotubes (CNTs); Bisphenol A (BPA); contaminants adsorption; environmental endocrine disrupting effect; reproductive toxicity
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Wang, W.; Jiang, C.; Zhu, L.; Liang, N.; Liu, X.; Jia, J.; Zhang, C.; Zhai, S.; Zhang, B. Adsorption of Bisphenol A to a Carbon Nanotube Reduced Its Endocrine Disrupting Effect in Mice Male Offspring. Int. J. Mol. Sci. 2014, 15, 15981-15993.

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