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Int. J. Mol. Sci. 2014, 15(9), 15622-15637; doi:10.3390/ijms150915622

Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells

1
Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 88, Section 1, Fengxing Road, Tanzi Dist., Taichung 427, Taiwan
2
Department of Ophthalmology, Mackay Memorial Hospital, No. 690, Section 2, Guangfu Road, East Dist., Hsinchu 30071, Taiwan
3
Tzu Chi Stem Cells Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Chung-Yang Road, Hualien 970, Taiwan
4
Department of Urology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 88, Section 1, Fengxing Road, Tanzi Dist., Taichung 427, Taiwan
5
School of Medicine, Tzu Chi University, No. 701, Section 3, Chung-Yang Road, Hualien 970, Taiwan
6
Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Chung-Yang Road, Hualien 970, Taiwan
7
Institute of Medical Sciences, School of Medicine, Tzu Chi University, No. 701, Section 3, Chung-Yang Road, Hualien 970, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 15 June 2014 / Revised: 15 August 2014 / Accepted: 19 August 2014 / Published: 4 September 2014
(This article belongs to the Special Issue Molecular Research in Urology 2014)
View Full-Text   |   Download PDF [4128 KB, uploaded 4 September 2014]   |  

Abstract

Tanshinone IIA (Tan-IIA), one of the major lipophilic components isolated from the root of Salviae Miltiorrhizae, has been found to exhibit anticancer activity in various cancer cells. We have demonstrated that Tan-IIA induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. Here we explored the anticancer effect of Tan-IIA in human bladder cancer cell lines. Our results showed that Tan-IIA caused bladder cancer cell death in a time- and dose-dependent manner. Tan-IIA induced apoptosis through the mitochondria-dependent pathway in these bladder cancer cells. Tan-IIA also suppressed the migration of bladder cancer cells as revealed by the wound healing and transwell assays. Finally, combination therapy of Tan-IIA with a lower dose of cisplatin successfully killed bladder cancer cells, suggesting that Tan-IIA can serve as a potential anti-cancer agent in bladder cancer. View Full-Text
Keywords: Tanshinone IIA; bladder cancer; metastasis; cisplatin; combination therapy Tanshinone IIA; bladder cancer; metastasis; cisplatin; combination therapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chiu, S.-C.; Huang, S.-Y.; Chang, S.-F.; Chen, S.-P.; Chen, C.-C.; Lin, T.-H.; Liu, H.-H.; Tsai, T.-H.; Lee, S.-S.; Pang, C.-Y.; Hsieh, T.-F. Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells. Int. J. Mol. Sci. 2014, 15, 15622-15637.

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