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Int. J. Mol. Sci. 2014, 15(8), 13172-13191; doi:10.3390/ijms150813172

Receptor for Advanced Glycation End Products (RAGE) and Its Ligands: Focus on Spinal Cord Injury

1
Department of Anatomy, Yonsei University College of Medicine, Seoul 120-752, Korea
2
BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea
*
Author to whom correspondence should be addressed.
Received: 5 June 2014 / Revised: 7 July 2014 / Accepted: 21 July 2014 / Published: 25 July 2014
(This article belongs to the Special Issue Neuroprotective Strategies 2014)
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Abstract

Spinal cord injury (SCI) results in neuronal and glial death and the loss of axons at the injury site. Inflammation after SCI leads to the inhibition of tissue regeneration and reduced neuronal survival. In addition, the loss of axons after SCI results in functional loss below the site of injury accompanied by neuronal cell body’s damage. Consequently, reducing inflammation and promoting axonal regeneration after SCI is a worthy therapeutic goal. The receptor for advanced glycation end products (RAGE) is a transmembrane protein and receptor of the immunoglobulin superfamily. RAGE is implicated in inflammation and neurodegeneration. Several recent studies demonstrated an association between RAGE and central nervous system disorders through various mechanisms. However, the relationship between RAGE and SCI has not been shown. It is imperative to elucidate the association between RAGE and SCI, considering that RAGE relates to inflammation and axonal degeneration following SCI. Hence, the present review highlights recent research regarding RAGE as a compelling target for the treatment of SCI. View Full-Text
Keywords: receptor for advanced glycation end products (RAGE); spinal cord injury (SCI); inflammation; neurite outgrowth; Schwann cell receptor for advanced glycation end products (RAGE); spinal cord injury (SCI); inflammation; neurite outgrowth; Schwann cell
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MDPI and ACS Style

Song, J.; Lee, W.T.; Park, K.A.; Lee, J.E. Receptor for Advanced Glycation End Products (RAGE) and Its Ligands: Focus on Spinal Cord Injury. Int. J. Mol. Sci. 2014, 15, 13172-13191.

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