Int. J. Mol. Sci. 2014, 15(7), 11832-11846; doi:10.3390/ijms150711832
Review

The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence

Received: 31 March 2014; in revised form: 5 June 2014 / Accepted: 25 June 2014 / Published: 3 July 2014
(This article belongs to the Special Issue Brain Metastasis 2014)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Radiation therapy is an important modality used in the treatment of patients with brain metastatic disease and malignant gliomas. Post-treatment surveillance often involves serial magnetic resonance imaging. A challenge faced by clinicians is in the diagnosis and management of a suspicious gadolinium-enhancing lesion found on imaging. The suspicious lesion may represent post-treatment radiation effects (PTRE) such as pseudoprogression, radiation necrosis or tumor recurrence. Significant progress has been made in diagnostic imaging modalities to assist in differentiating these entities. Surgical and medical interventions have also been developed to treat PTRE. In this review, we discuss the pathophysiology, clinical presentation, diagnostic imaging modalities and provide an algorithm for the management of pseudoprogression, radiation necrosis and tumor recurrence.
Keywords: pseudoprogression; radiation necrosis; metastasis; glioma; recurrence
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MDPI and ACS Style

Parvez, K.; Parvez, A.; Zadeh, G. The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence. Int. J. Mol. Sci. 2014, 15, 11832-11846.

AMA Style

Parvez K, Parvez A, Zadeh G. The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence. International Journal of Molecular Sciences. 2014; 15(7):11832-11846.

Chicago/Turabian Style

Parvez, Kashif; Parvez, Aatif; Zadeh, Gelareh. 2014. "The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence." Int. J. Mol. Sci. 15, no. 7: 11832-11846.

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