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Int. J. Mol. Sci. 2014, 15(7), 11435-11445; doi:10.3390/ijms150711435

PKM2: The Thread Linking Energy Metabolism Reprogramming with Epigenetics in Cancer

1,2,3,5,* and 1,2,3,*
Cancer Research Institute, Central South University, Changsha 410078, China
Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China
Key Laboratory of Carcinogenesis, Ministry of Health, Changsha 410078, China
Center for Medicine Research, Xiangya Hospital, Central South University, Changsha 410008, China
Thoracic Surgery Department, 2nd Xiangya Hospital, Central South University, Changsha 410011, China
Authors to whom correspondence should be addressed.
Received: 23 April 2014 / Revised: 20 May 2014 / Accepted: 10 June 2014 / Published: 26 June 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [729 KB, uploaded 26 June 2014]   |  


Cancer metabolism reprogramming or alterations in epigenetics are linked to an incidence of cancer. It is apparent that epigenetic changes have been found in tumors, therefore, the complete epigenome and entire pathways relevant to cell metabolism are subject to epigenetic dysregulation. Here, we review the pyruvate kinase M2 (PKM2) isoform, a glycolytic enzyme involved in ATP generation and pyruvate production, which plays an essential role in tumor metabolism and growth, and also functions as a protein kinase that phosphorylates histones during genes transcription and chromatin remodeling. We also discuss the potential role of PKM2 in the dynamic integration between metabolic reprogramming and alterations in epigenetics during carcinogenesis and cancer progression. View Full-Text
Keywords: PKM2 (pyruvate kinase M2); metabolic reprogramming; epigenetics; chromatin remodeling PKM2 (pyruvate kinase M2); metabolic reprogramming; epigenetics; chromatin remodeling

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, L.; Shi, Y.; Liu, S.; Cao, Y.; Wang, X.; Tao, Y. PKM2: The Thread Linking Energy Metabolism Reprogramming with Epigenetics in Cancer. Int. J. Mol. Sci. 2014, 15, 11435-11445.

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