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Int. J. Mol. Sci. 2014, 15(6), 11126-11141; doi:10.3390/ijms150611126

TRAF6 Inhibition Rescues Dexamethasone-Induced Muscle Atrophy

1,*  and 1,2,*
1 Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, Jiangsu, China 2 The Orthopedic Institute of First Affiliated Hospital, General Hospital of Chinese PLA, Beijing 100048, China
* Authors to whom correspondence should be addressed.
Received: 2 May 2014 / Revised: 2 June 2014 / Accepted: 5 June 2014 / Published: 20 June 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Tumor necrosis factor receptor-associated factor 6 (TRAF6), a unique E3 ubiquitin ligase and adaptor protein, is involved in activation of various signaling cascades. Recent studies identify TRAF6 as one of the novel regulators of skeletal muscle atrophy. The role of TRAF6 in glucocorticoid-induced muscle atrophy, however, remains to be elucidated. In this study, we show that TRAF6 and its downstream signaling molecules, muscle atrophy F-box (MAFBx) and muscle ring finger 1 (MuRF1), were all upregulated in dexamethasone-induced atrophy of mouse C2C12 myotubes or mouse tibialis anterior (TA) muscle. To further investigate the role of TRAF6 in dexamethasone-induced muscle atrophy, TRAF6-siRNA was used to transfect cultured C2C12 myotubes or was injected into the TA muscle of mice respectively, and we note that TRAF6 knockdown attenuated dexamethasone-induced muscle atrophy in vitro and in vivo, and concomitantly decreased the expression of MuRF1 and MAFBx. Our findings suggest that a decreased expression of TRAF6 could rescue dexamethasone-induced skeletal muscle atrophy through, at least in part, regulation of the expression of MAFBx and MuRF1.
Keywords: TRAF6; muscle atrophy; glucocorticoid TRAF6; muscle atrophy; glucocorticoid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sun, H.; Gong, Y.; Qiu, J.; Chen, Y.; Ding, F.; Zhao, Q. TRAF6 Inhibition Rescues Dexamethasone-Induced Muscle Atrophy. Int. J. Mol. Sci. 2014, 15, 11126-11141.

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