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Int. J. Mol. Sci. 2014, 15(6), 11111-11125; doi:10.3390/ijms150611111
Article

New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells

1,†
, 1,†
, 2
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, 1,*  and 3,*
Received: 10 April 2014; in revised form: 1 June 2014 / Accepted: 4 June 2014 / Published: 20 June 2014
(This article belongs to the Section Green Chemistry)
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Abstract: Five new (48) and three known (13) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The structures of all compounds were elucidated through spectroscopic analysis including 2D-NMR and HR-MS. The absolute configuration of these compounds was established by X-ray diffraction analysis, comparison of NOESY spectra and biogenetic means. The cytotoxities of compounds 28 were evaluated in vitro against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines. Compounds 57 exhibited the highest activities with IC50 values of 11.8–30.1 μM in most cases. The SAR revealed that the introduction of hydroxyl group was able to significantly improve the activities of the compounds for most of the cell lines.
Keywords: dihydro-β-agarofuran; sesquiterpene; Parnassia wightiana; cytotoxicity dihydro-β-agarofuran; sesquiterpene; Parnassia wightiana; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lv, C.; Zheng, Z.-L.; Miao, F.; Geng, H.-L.; Zhou, L.; Liu, L.-P. New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells. Int. J. Mol. Sci. 2014, 15, 11111-11125.

AMA Style

Lv C, Zheng Z-L, Miao F, Geng H-L, Zhou L, Liu L-P. New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells. International Journal of Molecular Sciences. 2014; 15(6):11111-11125.

Chicago/Turabian Style

Lv, Chao; Zheng, Zuo-Lue; Miao, Fang; Geng, Hui-Ling; Zhou, Le; Liu, La-Ping. 2014. "New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells." Int. J. Mol. Sci. 15, no. 6: 11111-11125.



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