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Int. J. Mol. Sci. 2014, 15(6), 10926-10935; doi:10.3390/ijms150610926
Article

The Constituents of Michelia compressa var. formosana and Their Bioactivities

1,* , 2
, 3
, 4
, 5
, 6
, 6
 and 4,*
1 Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan 2 Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan 3 Department of Pharmacy, China Medical University, Taichung 40402, Taiwan 4 Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan 5 Department of Life Sciences, National Cheng Kung University, Tainan 70101, Taiwan 6 School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan
* Authors to whom correspondence should be addressed.
Received: 2 April 2014 / Revised: 8 May 2014 / Accepted: 19 May 2014 / Published: 17 June 2014
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7–3.68 μM.
Keywords: Michelia formosana; Magnoliaceae; NO inhibition; macrophage; cytotoxicity Michelia formosana; Magnoliaceae; NO inhibition; macrophage; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chan, Y.-Y.; Juang, S.-H.; Huang, G.-J.; Liao, Y.-R.; Chen, Y.-F.; Wu, C.-C.; Chang, H.-T.; Wu, T.-S. The Constituents of Michelia compressa var. formosana and Their Bioactivities. Int. J. Mol. Sci. 2014, 15, 10926-10935.

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