Int. J. Mol. Sci. 2014, 15(6), 10926-10935; doi:10.3390/ijms150610926
Article

The Constituents of Michelia compressa var. formosana and Their Bioactivities

1,* email, 2email, 3email, 4email, 5email, 6email, 6email and 4,* email
Received: 2 April 2014; in revised form: 8 May 2014 / Accepted: 19 May 2014 / Published: 17 June 2014
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7–3.68 μM.
Keywords: Michelia formosana; Magnoliaceae; NO inhibition; macrophage; cytotoxicity
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MDPI and ACS Style

Chan, Y.-Y.; Juang, S.-H.; Huang, G.-J.; Liao, Y.-R.; Chen, Y.-F.; Wu, C.-C.; Chang, H.-T.; Wu, T.-S. The Constituents of Michelia compressa var. formosana and Their Bioactivities. Int. J. Mol. Sci. 2014, 15, 10926-10935.

AMA Style

Chan Y-Y, Juang S-H, Huang G-J, Liao Y-R, Chen Y-F, Wu C-C, Chang H-T, Wu T-S. The Constituents of Michelia compressa var. formosana and Their Bioactivities. International Journal of Molecular Sciences. 2014; 15(6):10926-10935.

Chicago/Turabian Style

Chan, Yu-Yi; Juang, Shin-Hun; Huang, Guan-Jhong; Liao, Yu-Ren; Chen, Yu-Fon; Wu, Chia-Che; Chang, Hui-Ting; Wu, Tian-Shung. 2014. "The Constituents of Michelia compressa var. formosana and Their Bioactivities." Int. J. Mol. Sci. 15, no. 6: 10926-10935.


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