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Int. J. Mol. Sci. 2014, 15(6), 10926-10935; doi:10.3390/ijms150610926

The Constituents of Michelia compressa var. formosana and Their Bioactivities

1,* , 2
Received: 2 April 2014 / Revised: 8 May 2014 / Accepted: 19 May 2014 / Published: 17 June 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7–3.68 μM.
Keywords: Michelia formosana; Magnoliaceae; NO inhibition; macrophage; cytotoxicity Michelia formosana; Magnoliaceae; NO inhibition; macrophage; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chan, Y.-Y.; Juang, S.-H.; Huang, G.-J.; Liao, Y.-R.; Chen, Y.-F.; Wu, C.-C.; Chang, H.-T.; Wu, T.-S. The Constituents of Michelia compressa var. formosana and Their Bioactivities. Int. J. Mol. Sci. 2014, 15, 10926-10935.

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