Next Article in Journal
The Constituents of Michelia compressa var. formosana and Their Bioactivities
Next Article in Special Issue
PSNO: Predicting Cysteine S-Nitrosylation Sites by Incorporating Various Sequence-Derived Features into the General Form of Chou’s PseAAC
Previous Article in Journal
Activation of mGluR5 Attenuates NMDA-Induced Neurotoxicity through Disruption of the NMDAR-PSD-95 Complex and Preservation of Mitochondrial Function in Differentiated PC12 Cells
Previous Article in Special Issue
Qualitative Analysis of the Helical Electronic Energy of Inherently Chiral Calix[4]arenes: An Approach to Effectively Assign Their Absolute Configuration
Int. J. Mol. Sci. 2014, 15(6), 10908-10925; doi:10.3390/ijms150610908
Article

Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties

1,* , 1,†
, 2,†
, 3,†
, 4,†
 and 1,†
Received: 15 April 2014; in revised form: 7 June 2014 / Accepted: 10 June 2014 / Published: 17 June 2014
(This article belongs to the Special Issue Molecular Science for Drug Development and Biomedicine)
View Full-Text   |   Download PDF [503 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: In the present investigation, new hydrazinecarbothioamides 46 were synthesized by reaction of 4-(4-X-phenylsulfonyl)benzoic acids hydrazides (X= H, Cl, Br) 13 with 2,4-difluorophenyl isothiocyanate and further these were treated with sodium hydroxide to obtain 1,2,4-triazole-3-thione derivatives 79. The reaction of 79 with α-halogenated ketones, in basic media, afforded new S-alkylated derivatives 1015. The structures of the synthesized compounds have been established on the basis of 1H-NMR, 13C-NMR, IR, mass spectral studies and elemental analysis. The antioxidant activity of all compounds has been screened. Hydrazinecarbothioamides 46 showed excellent antioxidant activity and 1,2,4-triazole-3-thiones 79 showed good antioxidant activity using the DPPH method.
Keywords: hydrazinecarbothioamide; 1,2,4-triazole-3-thione; cyclization; alkylation; antioxidant activity, diarylsulfone, 2,4-difluorophenyl moiety hydrazinecarbothioamide; 1,2,4-triazole-3-thione; cyclization; alkylation; antioxidant activity, diarylsulfone, 2,4-difluorophenyl moiety
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Barbuceanu, S.-F.; Ilies, D.C.; Saramet, G.; Uivarosi, V.; Draghici, C.; Radulescu, V. Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties. Int. J. Mol. Sci. 2014, 15, 10908-10925.

AMA Style

Barbuceanu S-F, Ilies DC, Saramet G, Uivarosi V, Draghici C, Radulescu V. Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties. International Journal of Molecular Sciences. 2014; 15(6):10908-10925.

Chicago/Turabian Style

Barbuceanu, Stefania-Felicia; Ilies, Diana C.; Saramet, Gabriel; Uivarosi, Valentina; Draghici, Constantin; Radulescu, Valeria. 2014. "Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties." Int. J. Mol. Sci. 15, no. 6: 10908-10925.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert