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Int. J. Mol. Sci. 2014, 15(6), 10136-10149; doi:10.3390/ijms150610136
Article

Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis

1,2,†
, 3,4,5,†
, 1,2
, 6
, 7
, 8,9,10,*  and 1,2,9,11,12,*
1 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944,Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan 4 Department of Urology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan 5 Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan 6 Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan 7 Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan 8 School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan 9 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan 10 Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan 11 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan 12 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 12 April 2014 / Revised: 19 May 2014 / Accepted: 23 May 2014 / Published: 6 June 2014
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.
Keywords: soft coral; pregnane; Scleronephthya flexilis; cytotoxicity; MOLT-4 soft coral; pregnane; Scleronephthya flexilis; cytotoxicity; MOLT-4
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kuo, C.-Y.; Juan, Y.-S.; Lu, M.-C.; Chiang, M.Y.-N.; Dai, C.-F.; Wu, Y.-C.; Sung, P.-J. Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis. Int. J. Mol. Sci. 2014, 15, 10136-10149.

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