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Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944,Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan
Department of Urology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 12 April 2014 / Revised: 19 May 2014 / Accepted: 23 May 2014 / Published: 6 June 2014
Abstract Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.
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Kuo, C.-Y.; Juan, Y.-S.; Lu, M.-C.; Chiang, M.Y.-N.; Dai, C.-F.; Wu, Y.-C.; Sung, P.-J. Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis. Int. J. Mol. Sci. 2014, 15, 10136-10149.
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Kuo C-Y, Juan Y-S, Lu M-C, Chiang MY-N, Dai C-F, Wu Y-C, Sung P-J. Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis. International Journal of Molecular Sciences. 2014; 15(6):10136-10149.
Kuo, Chao-Ying; Juan, Yung-Shun; Lu, Mei-Chin; Chiang, Michael Y.-N.; Dai, Chang-Feng; Wu, Yang-Chang; Sung, Ping-Jyun. 2014. "Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis." Int. J. Mol. Sci. 15, no. 6: 10136-10149.
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