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Int. J. Mol. Sci. 2014, 15(6), 10136-10149; doi:10.3390/ijms150610136
Article

Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis

1,2,†
,
3,4,5,†
,
1,2
,
6
,
7
,
8,9,10,*  and 1,2,9,11,12,*
Received: 12 April 2014 / Revised: 19 May 2014 / Accepted: 23 May 2014 / Published: 6 June 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.
Keywords: soft coral; pregnane; Scleronephthya flexilis; cytotoxicity; MOLT-4 soft coral; pregnane; Scleronephthya flexilis; cytotoxicity; MOLT-4
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kuo, C.-Y.; Juan, Y.-S.; Lu, M.-C.; Chiang, M.Y.-N.; Dai, C.-F.; Wu, Y.-C.; Sung, P.-J. Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis. Int. J. Mol. Sci. 2014, 15, 10136-10149.

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