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Int. J. Mol. Sci. 2014, 15(5), 9117-9133; doi:10.3390/ijms15059117

Brain Metastasis-Initiating Cells: Survival of the Fittest

Received: 15 April 2014 / Revised: 12 May 2014 / Accepted: 13 May 2014 / Published: 22 May 2014
(This article belongs to the Special Issue Brain Metastasis 2014)
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Brain metastases (BMs) are the most common brain tumor in adults, developing in about 10% of adult cancer patients. It is not the incidence of BM that is alarming, but the poor patient prognosis. Even with aggressive treatments, median patient survival is only months. Despite the high rate of BM-associated mortality, very little research is conducted in this area. Lack of research and staggeringly low patient survival is indicative that a novel approach to BMs and their treatment is needed. The ability of a small subset of primary tumor cells to produce macrometastases is reminiscent of brain tumor-initiating cells (BTICs) or cancer stem cells (CSCs) hypothesized to form primary brain tumors. BTICs are considered stem cell-like due to their self-renewal and differentiation properties. Similar to the subset of cells forming metastases, BTICs are most often a rare subpopulation. Based on the functional definition of a TIC, cells capable of forming a BM could be considered to be brain metastasis-initiating cells (BMICs). These putative BMICs would not only have the ability to initiate tumor growth in a secondary niche, but also the machinery to escape the primary tumor, migrate through the circulation, and invade the neural niche.
Keywords: brain metastasis; brain tumor; cancer stem cell; brain metastasis-initiating cell; brain tumor-initiating cell brain metastasis; brain tumor; cancer stem cell; brain metastasis-initiating cell; brain tumor-initiating cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Singh, M.; Manoranjan, B.; Mahendram, S.; McFarlane, N.; Venugopal, C.; Singh, S.K. Brain Metastasis-Initiating Cells: Survival of the Fittest. Int. J. Mol. Sci. 2014, 15, 9117-9133.

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