Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2014, 15(5), 8024-8036; doi:10.3390/ijms15058024
Concept Paper

Docosahexaenoic Acid Supplementation during Pregnancy: A Potential Tool to Prevent Membrane Rupture and Preterm Labor

1
, 2
, 1
, 2,3
, 4
, 5
, 1
 and 6,*
Received: 17 March 2014; in revised form: 24 April 2014 / Accepted: 29 April 2014 / Published: 7 May 2014
(This article belongs to the Special Issue Nutritional Control of Metabolism)
View Full-Text   |   Download PDF [1088 KB, uploaded 19 June 2014]
Abstract: Polyunsaturated fatty acids (PUFAs) are required to maintain the fluidity, permeability and integrity of cell membranes. Maternal dietary supplementation with ω-3 PUFAs during pregnancy has beneficial effects, including increased gestational length and reduced risk of pregnancy complications. Significant amounts of ω-3 docosahexaenoic acid (DHA) are transferred from maternal to fetal blood, hence ensuring high levels of DHA in the placenta and fetal bloodstream and tissues. Fetal DHA demand increases exponentially with gestational age, especially in the third trimester, due to fetal development. According to the World Health Organization (WHO) and the Food and Agriculture Organization of the United Nations (FAO), a daily intake of DHA is recommended during pregnancy. Omega-3 PUFAs are involved in several anti-inflammatory, pro-resolving and anti-oxidative pathways. Several placental disorders, such as intrauterine growth restriction, premature rupture of membranes (PROM) and preterm-PROM (pPROM), are associated with placental inflammation and oxidative stress. This pilot study reports on a preliminary evaluation of the significance of the daily DHA administration on PROM and pPROM events in healthy pregnant women. Further extensive clinical trials will be necessary to fully elucidate the correlation between DHA administration during pregnancy and PROM/pPROM occurrence, which is related in turn to gestational duration and overall fetal health.
Keywords: pregnancy; maternal and fetal health; fetal growth; placental disorders; premature rupture of membranes (PROM); preterm-premature rupture of membranes (pPROM); DHA supplementation pregnancy; maternal and fetal health; fetal growth; placental disorders; premature rupture of membranes (PROM); preterm-premature rupture of membranes (pPROM); DHA supplementation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Pietrantoni, E.; Del Chierico, F.; Rigon, G.; Vernocchi, P.; Salvatori, G.; Manco, M.; Signore, F.; Putignani, L. Docosahexaenoic Acid Supplementation during Pregnancy: A Potential Tool to Prevent Membrane Rupture and Preterm Labor. Int. J. Mol. Sci. 2014, 15, 8024-8036.

AMA Style

Pietrantoni E, Del Chierico F, Rigon G, Vernocchi P, Salvatori G, Manco M, Signore F, Putignani L. Docosahexaenoic Acid Supplementation during Pregnancy: A Potential Tool to Prevent Membrane Rupture and Preterm Labor. International Journal of Molecular Sciences. 2014; 15(5):8024-8036.

Chicago/Turabian Style

Pietrantoni, Emanuela; Del Chierico, Federica; Rigon, Giuliano; Vernocchi, Pamela; Salvatori, Guglielmo; Manco, Melania; Signore, Fabrizio; Putignani, Lorenza. 2014. "Docosahexaenoic Acid Supplementation during Pregnancy: A Potential Tool to Prevent Membrane Rupture and Preterm Labor." Int. J. Mol. Sci. 15, no. 5: 8024-8036.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert