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Int. J. Mol. Sci. 2014, 15(5), 7281-7292; doi:10.3390/ijms15057281

Proteomic Study of Differential Protein Expression in Mouse Lung Tissues after Aerosolized Ricin Poisoning

1
Institute of Military Veterinary, Academy of Military Medical Sciences, 666 West Liuying Road, Changchun 130122, Jilin, China
2
263 Clinical Department of General Hospital of Beijing Military Region, Beijing 101149, China
3
Medical Information Center of Chinese PLA General Hospital, Beijing 100853, China
4
College of Animal Science and Technology, Jilin Agricultural University, Changchun 130122, Jilin, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 13 January 2014 / Revised: 31 March 2014 / Accepted: 14 April 2014 / Published: 28 April 2014
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Abstract

Ricin is one of the most poisonous natural toxins from plants and is classified as a Class B biological threat pathogen by the Centers for Disease Control and Prevention (CDC) of U.S.A. Ricin exposure can occur through oral or aerosol routes. Ricin poisoning has a rapid onset and a short incubation period. There is no effective treatment for ricin poisoning. In this study, an aerosolized ricin-exposed mouse model was developed and the pathology was investigated. The protein expression profile in the ricin-poisoned mouse lung tissue was analyzed using proteomic techniques to determine the proteins that were closely related to the toxicity of ricin. 2D gel electrophoresis, mass spectrometry and subsequent biological functional analysis revealed that six proteins including Apoa1 apolipoprotein, Ywhaz 14-3-3 protein, Prdx6 Uncharacterized Protein, Selenium-binding protein 1, HMGB1, and DPYL-2, were highly related to ricin poisoning.
Keywords: ricin; aerosol; lung injury; proteomics ricin; aerosol; lung injury; proteomics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Guo, Z.; Han, C.; Du, J.; Zhao, S.; Fu, Y.; Zheng, G.; Sun, Y.; Zhang, Y.; Liu, W.; Wan, J.; Qian, J.; Liu, L. Proteomic Study of Differential Protein Expression in Mouse Lung Tissues after Aerosolized Ricin Poisoning. Int. J. Mol. Sci. 2014, 15, 7281-7292.

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