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Xenobiotic Metabolism: The Effect of Acute Kidney Injury on Non-Renal Drug Clearance and Hepatic Drug Metabolism
Int. J. Mol. Sci. 2014, 15(4), 6990-7003; doi:10.3390/ijms15046990

Drug-Induced Hepatotoxicity: Metabolic, Genetic and Immunological Basis

Departments of Anesthesiology and Critical Care Medicine, Pediatrics and Pathology, Johns Hopkins University, 1800 Orleans Street, Suite 6349, Baltimore, MD 21287, USA
Received: 3 January 2014 / Revised: 10 April 2014 / Accepted: 14 April 2014 / Published: 22 April 2014
(This article belongs to the Special Issue Xenobiotic Metabolism)
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Drug-induced hepatotoxicity is a significant cause of acute liver failure and is usually the primary reason that therapeutic drugs are removed from the commercial market. Multiple mechanisms can culminate in drug hepatotoxicity. Metabolism, genetics and immunology separately and in concert play distinct and overlapping roles in this process. This review will cover papers we feel have addressed these mechanisms of drug-induced hepatotoxicity in adults following the consumption of commonly used medications. The aim is to generate discussion around “trigger point” papers where the investigators generated new science or provided additional contribution to existing science. Hopefully these discussions will assist in uncovering key areas that need further attention.
Keywords: drug induced liver injury (DILI); hepatotoxicity; pathogenesis drug induced liver injury (DILI); hepatotoxicity; pathogenesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Njoku, D.B. Drug-Induced Hepatotoxicity: Metabolic, Genetic and Immunological Basis. Int. J. Mol. Sci. 2014, 15, 6990-7003.

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