Next Article in Journal
Toxicity and Metabolism of Layered Double Hydroxide Intercalated with Levodopa in a Parkinson’s Disease Model
Previous Article in Journal
Single and Binge Methamphetamine Administrations Have Different Effects on the Levels of Dopamine D2 Autoreceptor and Dopamine Transporter in Rat Striatum
Article Menu

Export Article

Open AccessShort Communication
Int. J. Mol. Sci. 2014, 15(4), 5907-5915; doi:10.3390/ijms15045907

Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice

1
Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, Korea
2
Department of Tourism Food Service Cuisine, Hallym Polytechnic University, Gangwon 200-711, Korea
3
Department of Food Science and Technology, Seowon University, Cheongju, Chungbuk 361-742, Korea
*
Author to whom correspondence should be addressed.
Received: 16 December 2013 / Revised: 21 February 2014 / Accepted: 20 March 2014 / Published: 8 April 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [357 KB, uploaded 19 June 2014]   |  

Abstract

In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were down regulated in feeding the fermented C. lanceolata (FCL). Another 374 genes were up regulated and 527 genes down regulated without feeding the sample. The genes were not affected by the FCL sample. It was interesting that among those genes, Chytochrome P450, Dmbt1, LOC76487, and thyroid hormones, etc., were mostly up or down regulated. These genes are more related to lipid synthesis. We could conclude that the FCL possibly controlled the gene expression levels related to lipid synthesis, which resulted in reducing obesity. However, more detailed protein expression experiments should be carried out. View Full-Text
Keywords: fermented Codonopsis lanceolata; microarray; gene expression; obesity fermented Codonopsis lanceolata; microarray; gene expression; obesity
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Choi, W.Y.; Kim, J.S.; Park, S.J.; Ma, C.J.; Lee, H.Y. Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice. Int. J. Mol. Sci. 2014, 15, 5907-5915.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top