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Int. J. Mol. Sci. 2014, 15(4), 5263-5276; doi:10.3390/ijms15045263
Article

Endothelialization of Novel Magnesium-Rare Earth Alloys with Fluoride and Collagen Coating

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Received: 23 January 2014; in revised form: 10 March 2014 / Accepted: 13 March 2014 / Published: 25 March 2014
(This article belongs to the Special Issue Biodegradable Magnesium Alloys and Implants)
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Abstract: Magnesium (Mg) alloys are promising scaffolds for the next generation of cardiovascular stents because of their better biocompatibility and biodegradation compared to traditional metals. However, insufficient mechanical strength and high degradation rate are still the two main limitations for Mg materials. Hydrofluoric acid (HF) treatment and collagen coating were used in this research to improve the endothelialization of two rare earth-based Mg alloys. Results demonstrated that a nanoporous film structure of fluoride with thickness of ~20 µm was formed on the Mg material surface, which improved the corrosion resistance. Primary human coronary artery endothelial cells (HCAECs) had much better attachment, spreading, growth and proliferation (the process of endothelialization) on HF-treated Mg materials compared to bare- or collagen-coated ones.
Keywords: magnesium; rare earth elements; corrosion; surface coating; biocompatibility magnesium; rare earth elements; corrosion; surface coating; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhao, N.; Workman, B.; Zhu, D. Endothelialization of Novel Magnesium-Rare Earth Alloys with Fluoride and Collagen Coating. Int. J. Mol. Sci. 2014, 15, 5263-5276.

AMA Style

Zhao N, Workman B, Zhu D. Endothelialization of Novel Magnesium-Rare Earth Alloys with Fluoride and Collagen Coating. International Journal of Molecular Sciences. 2014; 15(4):5263-5276.

Chicago/Turabian Style

Zhao, Nan; Workman, Benjamin; Zhu, Donghui. 2014. "Endothelialization of Novel Magnesium-Rare Earth Alloys with Fluoride and Collagen Coating." Int. J. Mol. Sci. 15, no. 4: 5263-5276.


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