Next Article in Journal
Antibacterial Activity of New Oxazolidin-2-One Analogues in Methicillin-Resistant Staphylococcus aureus Strains
Next Article in Special Issue
Optimization of Cell Adhesion on Mg Based Implant Materials by Pre-Incubation under Cell Culture Conditions
Previous Article in Journal
Solar Light Photocatalytic CO2 Reduction: General Considerations and Selected Bench-Mark Photocatalysts
Previous Article in Special Issue
Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(4), 5263-5276; doi:10.3390/ijms15045263

Endothelialization of Novel Magnesium-Rare Earth Alloys with Fluoride and Collagen Coating

Department of Chemical, Biological and Bio-Engineering, NSF Engineering Research Center-Revolutionizing Metallic Biomaterials, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 23 January 2014 / Revised: 10 March 2014 / Accepted: 13 March 2014 / Published: 25 March 2014
(This article belongs to the Special Issue Biodegradable Magnesium Alloys and Implants)
View Full-Text   |   Download PDF [1822 KB, uploaded 19 June 2014]   |  


Magnesium (Mg) alloys are promising scaffolds for the next generation of cardiovascular stents because of their better biocompatibility and biodegradation compared to traditional metals. However, insufficient mechanical strength and high degradation rate are still the two main limitations for Mg materials. Hydrofluoric acid (HF) treatment and collagen coating were used in this research to improve the endothelialization of two rare earth-based Mg alloys. Results demonstrated that a nanoporous film structure of fluoride with thickness of ~20 µm was formed on the Mg material surface, which improved the corrosion resistance. Primary human coronary artery endothelial cells (HCAECs) had much better attachment, spreading, growth and proliferation (the process of endothelialization) on HF-treated Mg materials compared to bare- or collagen-coated ones.
Keywords: magnesium; rare earth elements; corrosion; surface coating; biocompatibility magnesium; rare earth elements; corrosion; surface coating; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhao, N.; Workman, B.; Zhu, D. Endothelialization of Novel Magnesium-Rare Earth Alloys with Fluoride and Collagen Coating. Int. J. Mol. Sci. 2014, 15, 5263-5276.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top