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Int. J. Mol. Sci. 2014, 15(5), 7639-7650; doi:10.3390/ijms15057639

Optimization of Cell Adhesion on Mg Based Implant Materials by Pre-Incubation under Cell Culture Conditions

Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Max-Planck-Str. 1, Geesthacht 21502, Germany
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Received: 27 February 2014 / Revised: 20 March 2014 / Accepted: 16 April 2014 / Published: 5 May 2014
(This article belongs to the Special Issue Biodegradable Magnesium Alloys and Implants)
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Abstract

Magnesium based implants could revolutionize applications where orthopedic implants such as nails, screws or bone plates are used because they are load bearing and degrade over time. This prevents a second surgery to remove conventional implants. To improve the biocompatibility we studied here if and for how long a pre-incubation of the material under cell culture conditions is favorable for cell attachment and proliferation. For two materials, Mg and Mg10Gd1Nd, we could show that 6 h pre-incubation are already enough to form a natural protective layer suitable for cell culture. View Full-Text
Keywords: magnesium implants; natural corrosion protection; pre-incubation; biocompatibility magnesium implants; natural corrosion protection; pre-incubation; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Willumeit, R.; Möhring, A.; Feyerabend, F. Optimization of Cell Adhesion on Mg Based Implant Materials by Pre-Incubation under Cell Culture Conditions. Int. J. Mol. Sci. 2014, 15, 7639-7650.

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