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Int. J. Mol. Sci. 2014, 15(3), 4531-4549; doi:10.3390/ijms15034531

Structural and Molecular Modeling Features of P2X Receptors

1,* , 2
1 Cell Communication Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), 4365 Brazil ave, Rio de Janeiro 21045-900, Brazil 2 Oswaldo Cruz Foundation (FIOCRUZ) Ceará Avenida Santos Dumont, 5753, Torre Saúde, Sala 1303, Papicu, Fortaleza-CE, CEP 60180-900, Brazil 3 Scientific Computation Program, Oswaldo Cruz Foundation (FIOCRUZ), 4365 Brazil ave, Rio de Janeiro 21045-900, Brazil 4 National Nuclear Magnetic Resonance Center (CNRMN), The National Institute of Science and Technology for Structural Biology and Bioimaging, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro (UFRJ), Carlos Chagas Filho, 373, Rio de Janeiro 21941-901, Brazil
* Author to whom correspondence should be addressed.
Received: 16 September 2013 / Revised: 5 December 2013 / Accepted: 10 December 2013 / Published: 14 March 2014
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Currently, adenosine 5'-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic receptors and P2X ionotropic receptors, both of which are found in virtually all mammalian cell types studied. Due to the difficulty in studying membrane protein structures by X-ray crystallography or NMR techniques, there is little information about these structures available in the literature. Two structures of the P2X4 receptor in truncated form have been solved by crystallography. Molecular modeling has proven to be an excellent tool for studying ionotropic receptors. Recently, modeling studies carried out on P2X receptors have advanced our knowledge of the P2X receptor structure-function relationships. This review presents a brief history of ion channel structural studies and shows how modeling approaches can be used to address relevant questions about P2X receptors.
Keywords: P2X7 receptor; ion channel activity; patch-clamp P2X7 receptor; ion channel activity; patch-clamp
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Alves, L.A.; da Silva, J.H.M.; Ferreira, D.N.M.; Fidalgo-Neto, A.A.; Teixeira, P.C.N.; de Souza, C.A.M.; Caffarena, E.R.; de Freitas, M.S. Structural and Molecular Modeling Features of P2X Receptors. Int. J. Mol. Sci. 2014, 15, 4531-4549.

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