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Int. J. Mol. Sci. 2014, 15(3), 4531-4549; doi:10.3390/ijms15034531
Review

Structural and Molecular Modeling Features of P2X Receptors

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Received: 16 September 2013; in revised form: 5 December 2013 / Accepted: 10 December 2013 / Published: 14 March 2014
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Abstract: Currently, adenosine 5'-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic receptors and P2X ionotropic receptors, both of which are found in virtually all mammalian cell types studied. Due to the difficulty in studying membrane protein structures by X-ray crystallography or NMR techniques, there is little information about these structures available in the literature. Two structures of the P2X4 receptor in truncated form have been solved by crystallography. Molecular modeling has proven to be an excellent tool for studying ionotropic receptors. Recently, modeling studies carried out on P2X receptors have advanced our knowledge of the P2X receptor structure-function relationships. This review presents a brief history of ion channel structural studies and shows how modeling approaches can be used to address relevant questions about P2X receptors.
Keywords: P2X7 receptor; ion channel activity; patch-clamp P2X7 receptor; ion channel activity; patch-clamp
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Alves, L.A.; da Silva, J.H.M.; Ferreira, D.N.M.; Fidalgo-Neto, A.A.; Teixeira, P.C.N.; de Souza, C.A.M.; Caffarena, E.R.; de Freitas, M.S. Structural and Molecular Modeling Features of P2X Receptors. Int. J. Mol. Sci. 2014, 15, 4531-4549.

AMA Style

Alves LA, da Silva JHM, Ferreira DNM, Fidalgo-Neto AA, Teixeira PCN, de Souza CAM, Caffarena ER, de Freitas MS. Structural and Molecular Modeling Features of P2X Receptors. International Journal of Molecular Sciences. 2014; 15(3):4531-4549.

Chicago/Turabian Style

Alves, Luiz A.; da Silva, João H.M.; Ferreira, Dinarte N.M.; Fidalgo-Neto, Antonio A.; Teixeira, Pedro C.N.; de Souza, Cristina A.M.; Caffarena, Ernesto R.; de Freitas, Mônica S. 2014. "Structural and Molecular Modeling Features of P2X Receptors." Int. J. Mol. Sci. 15, no. 3: 4531-4549.


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