Next Article in Journal
New Unsymmetrically Benzene-Fused Bis (Tetrathiafulvalene): Synthesis, Characterization, Electrochemical Properties and Electrical Conductivity of Their Materials
Previous Article in Journal
A Preliminary X-ray Study of Murine Tnfaip8/Oxi-α
Int. J. Mol. Sci. 2014, 15(3), 4531-4549; doi:10.3390/ijms15034531

Structural and Molecular Modeling Features of P2X Receptors

1,* , 2
, 1
, 1
, 1
, 1
, 3
 and 4
Received: 16 September 2013 / Revised: 5 December 2013 / Accepted: 10 December 2013 / Published: 14 March 2014
View Full-Text   |   Download PDF [1150 KB, updated 19 June 2014; original version uploaded 19 June 2014]   |   Browse Figures
Abstract: Currently, adenosine 5'-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic receptors and P2X ionotropic receptors, both of which are found in virtually all mammalian cell types studied. Due to the difficulty in studying membrane protein structures by X-ray crystallography or NMR techniques, there is little information about these structures available in the literature. Two structures of the P2X4 receptor in truncated form have been solved by crystallography. Molecular modeling has proven to be an excellent tool for studying ionotropic receptors. Recently, modeling studies carried out on P2X receptors have advanced our knowledge of the P2X receptor structure-function relationships. This review presents a brief history of ion channel structural studies and shows how modeling approaches can be used to address relevant questions about P2X receptors.
Keywords: P2X7 receptor; ion channel activity; patch-clamp P2X7 receptor; ion channel activity; patch-clamp
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Alves, L.A.; da Silva, J.H.M.; Ferreira, D.N.M.; Fidalgo-Neto, A.A.; Teixeira, P.C.N.; de Souza, C.A.M.; Caffarena, E.R.; de Freitas, M.S. Structural and Molecular Modeling Features of P2X Receptors. Int. J. Mol. Sci. 2014, 15, 4531-4549.

AMA Style

Alves LA, da Silva JHM, Ferreira DNM, Fidalgo-Neto AA, Teixeira PCN, de Souza CAM, Caffarena ER, de Freitas MS. Structural and Molecular Modeling Features of P2X Receptors. International Journal of Molecular Sciences. 2014; 15(3):4531-4549.

Chicago/Turabian Style

Alves, Luiz A.; da Silva, João H.M.; Ferreira, Dinarte N.M.; Fidalgo-Neto, Antonio A.; Teixeira, Pedro C.N.; de Souza, Cristina A.M.; Caffarena, Ernesto R.; de Freitas, Mônica S. 2014. "Structural and Molecular Modeling Features of P2X Receptors." Int. J. Mol. Sci. 15, no. 3: 4531-4549.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert