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Int. J. Mol. Sci. 2014, 15(3), 4523-4530; doi:10.3390/ijms15034523

A Preliminary X-ray Study of Murine Tnfaip8/Oxi-α

Received: 28 January 2014 / Revised: 6 March 2014 / Accepted: 7 March 2014 / Published: 14 March 2014
(This article belongs to the Special Issue Redox Signaling in Biology and Patho-Biology)
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Tnfaip8/oxidative stress regulated gene-α (Oxi-α) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi-α has been crystallized and X-ray data have been collected to 1.8 Å using synchrotron radiation. The crystal belonged to the primitive orthorhombic space group P21212, with unit-cell parameters a = 66.9, b = 72.3, c = 93.5 Å. A full structural determination is under way in order to provide insights into the structure-function relationships of this protein.
Keywords: Parkinson’s disease; Oxi-α; oxidative stress; C165S mutant; X-ray crystallography Parkinson’s disease; Oxi-α; oxidative stress; C165S mutant; X-ray crystallography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lee, D.; Kim, M.-S.; Park, J.; Jhon, G.-J.; Son, J.H.; Shin, D.H. A Preliminary X-ray Study of Murine Tnfaip8/Oxi-α. Int. J. Mol. Sci. 2014, 15, 4523-4530.

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