Next Article in Journal
Structural and Molecular Modeling Features of P2X Receptors
Next Article in Special Issue
Block of the Mevalonate Pathway Triggers Oxidative and Inflammatory Molecular Mechanisms Modulated by Exogenous Isoprenoid Compounds
Previous Article in Journal
Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation
Previous Article in Special Issue
Dynamin-Related Protein 1 Inhibitors Protect against Ischemic Toxicity through Attenuating Mitochondrial Ca2+ Uptake from Endoplasmic Reticulum Store in PC12 Cells
Int. J. Mol. Sci. 2014, 15(3), 4523-4530; doi:10.3390/ijms15034523
Article

A Preliminary X-ray Study of Murine Tnfaip8/Oxi-α

1,†
,
1,†
,
1
,
2
,
1
 and
1,*
1 College of Pharmacy and Graduate School of Pharmaceutical Sciences, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea 2 Department of Chemistry and Nano Science, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 28 January 2014 / Revised: 6 March 2014 / Accepted: 7 March 2014 / Published: 14 March 2014
(This article belongs to the Special Issue Redox Signaling in Biology and Patho-Biology)
View Full-Text   |   Download PDF [413 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

Tnfaip8/oxidative stress regulated gene-α (Oxi-α) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi-α has been crystallized and X-ray data have been collected to 1.8 Å using synchrotron radiation. The crystal belonged to the primitive orthorhombic space group P21212, with unit-cell parameters a = 66.9, b = 72.3, c = 93.5 Å. A full structural determination is under way in order to provide insights into the structure-function relationships of this protein.
Keywords: Parkinson’s disease; Oxi-α; oxidative stress; C165S mutant; X-ray crystallography Parkinson’s disease; Oxi-α; oxidative stress; C165S mutant; X-ray crystallography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Lee, D.; Kim, M.-S.; Park, J.; Jhon, G.-J.; Son, J.H.; Shin, D.H. A Preliminary X-ray Study of Murine Tnfaip8/Oxi-α. Int. J. Mol. Sci. 2014, 15, 4523-4530.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert