Int. J. Mol. Sci. 2014, 15(3), 4257-4272; doi:10.3390/ijms15034257
Article

Synthesis, Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone Hydrazone Derivatives as Potential Antifungal Agents

Received: 23 January 2014; in revised form: 24 February 2014 / Accepted: 4 March 2014 / Published: 11 March 2014
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Aimed at developing novel fungicides for relieving the ever-increasing pressure of agricultural production caused by phytopathogenic fungi, 28 new hydrazone derivatives of carabrone, a natural bioactive sesquisterpene, in three types were designed, synthesized and their antifungal activities against Botrytis cinerea and Colletotrichum lagenarium were evaluated. The result revealed that all the derivatives synthesized exhibited considerable antifungal activities in vitro and in vivo, which led to the improved activities for carabrone and its analogues and further confirmed their potential as antifungal agents.
Keywords: carabrone; hydrazone derivatives; chemical modification; antifungal activity; structure–activity relationship
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MDPI and ACS Style

Wang, H.; Ren, S.-X.; He, Z.-Y.; Wang, D.-L.; Yan, X.-N.; Feng, J.-T.; Zhang, X. Synthesis, Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone Hydrazone Derivatives as Potential Antifungal Agents. Int. J. Mol. Sci. 2014, 15, 4257-4272.

AMA Style

Wang H, Ren S-X, He Z-Y, Wang D-L, Yan X-N, Feng J-T, Zhang X. Synthesis, Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone Hydrazone Derivatives as Potential Antifungal Agents. International Journal of Molecular Sciences. 2014; 15(3):4257-4272.

Chicago/Turabian Style

Wang, Hao; Ren, Shuang-Xi; He, Ze-Yu; Wang, De-Long; Yan, Xiao-Nan; Feng, Jun-Tao; Zhang, Xing. 2014. "Synthesis, Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone Hydrazone Derivatives as Potential Antifungal Agents." Int. J. Mol. Sci. 15, no. 3: 4257-4272.

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