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Int. J. Mol. Sci. 2014, 15(3), 4273-4283; doi:10.3390/ijms15034273

Polymorphisms in DNA Repair Genes (APEX1, XPD, XRCC1 and XRCC3) and Risk of Preeclampsia in a Mexican Mestizo Population

1 Institute for Scientific Research, Juarez University of Durango State, 34000 Durango, Mexico 2 Faculty of Medicine and Nutrition, Juarez University of Durango State, 34000 Durango, Mexico 3 General Hospital of Durango, Secretary of Health, Durango, 34000 Durango, Mexico
* Author to whom correspondence should be addressed.
Received: 21 January 2014 / Revised: 17 February 2014 / Accepted: 4 March 2014 / Published: 11 March 2014
(This article belongs to the collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Variations in genes involved in DNA repair systems have been proposed as risk factors for the development of preeclampsia (PE). We conducted a case-control study to investigate the association of Human apurinic/apyrimidinic (AP) endonuclease (APEX1) Asp148Glu (rs1130409), Xeroderma Pigmentosum group D (XPD) Lys751Gln (rs13181), X-ray repair cross-complementing group 1 (XRCC) Arg399Gln (rs25487) and X-ray repair cross-complementing group 3 (XRCC3) Thr241Met (rs861539) polymorphisms with PE in a Mexican population. Samples of 202 cases and 350 controls were genotyped using RTPCR. Association analyses based on a χ2 test and binary logistic regression were performed to determine the odds ratio (OR) and a 95% confidence interval (95% CI) for each polymorphism. The allelic frequencies of APEX1 Asp148Glu polymorphism showed statistical significant differences between preeclamptic and normal women (p = 0.036). Although neither of the polymorphisms proved to be a risk factor for the disease, the APEX1 Asp148Glu polymorphism showed a tendency of association (OR: 1.74, 95% CI = 0.96–3.14) and a significant trend (p for trend = 0.048). A subgroup analyses revealed differences in the allelic frequencies of APEX1 Asp148Glu polymorphism between women with mild preeclampsia and severe preeclampsia (p = 0.035). In conclusion, our results reveal no association between XPD Lys751Gln, XRCC Arg399Gln and XRCC3 Thr241Met polymorphisms and the risk of PE in a Mexican mestizo population; however, the results in the APEX1 Asp148Glu polymorphism suggest the need for future studies using a larger sample size.
Keywords: preeclampsia; polymorphisms; APEX1; XPD; XRCC1; XRCC3 preeclampsia; polymorphisms; APEX1; XPD; XRCC1; XRCC3
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sandoval-Carrillo, A.; Méndez-Hernández, E.M.; Vazquez-Alaniz, F.; Aguilar-Durán, M.; Téllez-Valencia, A.; Barraza-Salas, M.; Castellanos-Juárez, F.X.; Llave-León, O.L.; Salas-Pacheco, J.M. Polymorphisms in DNA Repair Genes (APEX1, XPD, XRCC1 and XRCC3) and Risk of Preeclampsia in a Mexican Mestizo Population. Int. J. Mol. Sci. 2014, 15, 4273-4283.

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