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Int. J. Mol. Sci. 2014, 15(3), 4158-4188; doi:10.3390/ijms15034158

Modulation of Gut Microbiota in the Management of Metabolic Disorders: The Prospects and Challenges

Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
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Received: 28 October 2013 / Revised: 12 February 2014 / Accepted: 21 February 2014 / Published: 7 March 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [261 KB, 19 June 2014; original version 19 June 2014]

Abstract

The gut microbiota plays a number of important roles including digestion, metabolism, extraction of nutrients, synthesis of vitamins, prevention against pathogen colonization, and modulation of the immune system. Alterations or changes in composition and biodiversity of the gut microbiota have been associated with many gastrointestinal tract (GIT) disorders such as inflammatory bowel disease and colon cancer. Recent evidence suggests that altered composition and diversity of gut microbiota may play a role in the increased prevalence of metabolic diseases. This review article has two main objectives. First, it underscores approaches (such as probiotics, prebiotics, antimicrobial agents, bariatric surgery, and weight loss strategies) and their prospects in modulating the gut microbiota in the management of metabolic diseases. Second, it highlights some of the current challenges and discusses areas of future research as it relates to the gut microbiota and metabolic diseases. The prospect of modulating the gut microbiota seems promising. However, considering that research investigating the role of gut microbiota in metabolic diseases is still in its infancy, more rigorous and well-designed in vitro, animal and clinical studies are needed. View Full-Text
Keywords: gut microbiota; gut microbiome; microbes; prebiotics; probiotics; fiber, antimicrobial agents; bariatric surgery; metabolic diseases; obesity; diabetes mellitus gut microbiota; gut microbiome; microbes; prebiotics; probiotics; fiber, antimicrobial agents; bariatric surgery; metabolic diseases; obesity; diabetes mellitus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Erejuwa, O.O.; Sulaiman, S.A.; Wahab, M.S.A. Modulation of Gut Microbiota in the Management of Metabolic Disorders: The Prospects and Challenges. Int. J. Mol. Sci. 2014, 15, 4158-4188.

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