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Int. J. Mol. Sci. 2014, 15(3), 3926-3951; doi:10.3390/ijms15033926
Article

Synthesis of Analogues of Gingerol and Shogaol, the Active Pungent Principles from the Rhizomes of Zingiber officinale and Evaluation of Their Anti-Platelet Aggregation Effects

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Received: 2 January 2014; in revised form: 17 February 2014 / Accepted: 21 February 2014 / Published: 4 March 2014
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: The present study was aimed at discovering novel biologically active compounds based on the skeletons of gingerol and shogaol, the pungent principles from the rhizomes of Zingiber officinale. Therefore, eight groups of analogues were synthesized and examined for their inhibitory activities of platelet aggregation induced by arachidonic acid, collagen, platelet activating factor, and thrombin. Among the tested compounds, [6]-paradol (5b) exhibited the most significant anti-platelet aggregation activity. It was the most potent candidate, which could be used in further investigation to explore new drug leads.
Keywords: Zingiber officinale; ginger; gingerol; shogaol; anti-platelet aggregation Zingiber officinale; ginger; gingerol; shogaol; anti-platelet aggregation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shih, H.-C.; Chern, C.-Y.; Kuo, P.-C.; Wu, Y.-C.; Chan, Y.-Y.; Liao, Y.-R.; Teng, C.-M.; Wu, T.-S. Synthesis of Analogues of Gingerol and Shogaol, the Active Pungent Principles from the Rhizomes of Zingiber officinale and Evaluation of Their Anti-Platelet Aggregation Effects. Int. J. Mol. Sci. 2014, 15, 3926-3951.

AMA Style

Shih H-C, Chern C-Y, Kuo P-C, Wu Y-C, Chan Y-Y, Liao Y-R, Teng C-M, Wu T-S. Synthesis of Analogues of Gingerol and Shogaol, the Active Pungent Principles from the Rhizomes of Zingiber officinale and Evaluation of Their Anti-Platelet Aggregation Effects. International Journal of Molecular Sciences. 2014; 15(3):3926-3951.

Chicago/Turabian Style

Shih, Hung-Cheng; Chern, Ching-Yuh; Kuo, Ping-Chung; Wu, You-Cheng; Chan, Yu-Yi; Liao, Yu-Ren; Teng, Che-Ming; Wu, Tian-Shung. 2014. "Synthesis of Analogues of Gingerol and Shogaol, the Active Pungent Principles from the Rhizomes of Zingiber officinale and Evaluation of Their Anti-Platelet Aggregation Effects." Int. J. Mol. Sci. 15, no. 3: 3926-3951.



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