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Int. J. Mol. Sci. 2014, 15(3), 3889-3903; doi:10.3390/ijms15033889
Article

Osthole Suppresses the Migratory Ability of Human Glioblastoma Multiforme Cells via Inhibition of Focal Adhesion Kinase-Mediated Matrix Metalloproteinase-13 Expression

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Received: 10 January 2014; in revised form: 24 February 2014 / Accepted: 25 February 2014 / Published: 4 March 2014
(This article belongs to the Section Molecular Pathology)
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Abstract: Glioblastoma multiforme (GBM) is the most common type of primary and malignant tumor occurring in the adult central nervous system. GBM often invades surrounding regions of the brain during its early stages, making successful treatment difficult. Osthole, an active constituent isolated from the dried C. monnieri fruit, has been shown to suppress tumor migration and invasion. However, the effects of osthole in human GBM are largely unknown. Focal adhesion kinase (FAK) is important for the metastasis of cancer cells. Results from this study show that osthole can not only induce cell death but also inhibit phosphorylation of FAK in human GBM cells. Results from this study show that incubating GBM cells with osthole reduces matrix metalloproteinase (MMP)-13 expression and cell motility, as assessed by cell transwell and wound healing assays. This study also provides evidence supporting the potential of osthole in reducing FAK activation, MMP-13 expression, and cell motility in human GBM cells.
Keywords: osthole; GBM; FAK; MMP-13; cell migration osthole; GBM; FAK; MMP-13; cell migration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Tsai, C.-F.; Yeh, W.-L.; Chen, J.-H.; Lin, C.; Huang, S.-S.; Lu, D.-Y. Osthole Suppresses the Migratory Ability of Human Glioblastoma Multiforme Cells via Inhibition of Focal Adhesion Kinase-Mediated Matrix Metalloproteinase-13 Expression. Int. J. Mol. Sci. 2014, 15, 3889-3903.

AMA Style

Tsai C-F, Yeh W-L, Chen J-H, Lin C, Huang S-S, Lu D-Y. Osthole Suppresses the Migratory Ability of Human Glioblastoma Multiforme Cells via Inhibition of Focal Adhesion Kinase-Mediated Matrix Metalloproteinase-13 Expression. International Journal of Molecular Sciences. 2014; 15(3):3889-3903.

Chicago/Turabian Style

Tsai, Cheng-Fang; Yeh, Wei-Lan; Chen, Jia-Hong; Lin, Chingju; Huang, Shiang-Suo; Lu, Dah-Yuu. 2014. "Osthole Suppresses the Migratory Ability of Human Glioblastoma Multiforme Cells via Inhibition of Focal Adhesion Kinase-Mediated Matrix Metalloproteinase-13 Expression." Int. J. Mol. Sci. 15, no. 3: 3889-3903.



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