Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions
AbstractLinear polysaccharides are typically composed of repeating mono- or disaccharide units and are ubiquitous among living organisms. Polysaccharide diversity arises from chain-length variation, branching, and additional modifications. Structural diversity is associated with various physiological functions, which are often regulated by cognate polysaccharide-binding proteins. Proteins that interact with linear polysaccharides have been identified or developed, such as galectins and polysaccharide-specific antibodies, respectively. Currently, data is accumulating on the three-dimensional structure of polysaccharide-binding proteins. These proteins are classified into two types: exo-type and endo-type. The former group specifically interacts with the terminal units of polysaccharides, whereas the latter with internal units. In this review, we describe the structural aspects of exo-type and endo-type protein-polysaccharide interactions. Further, we discuss the structural basis for affinity and specificity enhancement in the face of inherently weak binding interactions.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Nagae, M.; Yamaguchi, Y. Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions. Int. J. Mol. Sci. 2014, 15, 3768-3783.
Nagae M, Yamaguchi Y. Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions. International Journal of Molecular Sciences. 2014; 15(3):3768-3783.Chicago/Turabian Style
Nagae, Masamichi; Yamaguchi, Yoshiki. 2014. "Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions." Int. J. Mol. Sci. 15, no. 3: 3768-3783.