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Int. J. Mol. Sci. 2014, 15(3), 3768-3783; doi:10.3390/ijms15033768
Review

Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions

 and *
Received: 26 December 2013; in revised form: 17 February 2014 / Accepted: 21 February 2014 / Published: 3 March 2014
(This article belongs to the Special Issue Glycosylation and Glycoproteins)
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Abstract: Linear polysaccharides are typically composed of repeating mono- or disaccharide units and are ubiquitous among living organisms. Polysaccharide diversity arises from chain-length variation, branching, and additional modifications. Structural diversity is associated with various physiological functions, which are often regulated by cognate polysaccharide-binding proteins. Proteins that interact with linear polysaccharides have been identified or developed, such as galectins and polysaccharide-specific antibodies, respectively. Currently, data is accumulating on the three-dimensional structure of polysaccharide-binding proteins. These proteins are classified into two types: exo-type and endo-type. The former group specifically interacts with the terminal units of polysaccharides, whereas the latter with internal units. In this review, we describe the structural aspects of exo-type and endo-type protein-polysaccharide interactions. Further, we discuss the structural basis for affinity and specificity enhancement in the face of inherently weak binding interactions.
Keywords: polysaccharide; lectin; 3D structure; polylactosamine; galectin; carbohydrate binding module; β-glucan; polysialic acid; antibody; affinity; hyaluronan; CD44 polysaccharide; lectin; 3D structure; polylactosamine; galectin; carbohydrate binding module; β-glucan; polysialic acid; antibody; affinity; hyaluronan; CD44
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nagae, M.; Yamaguchi, Y. Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions. Int. J. Mol. Sci. 2014, 15, 3768-3783.

AMA Style

Nagae M, Yamaguchi Y. Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions. International Journal of Molecular Sciences. 2014; 15(3):3768-3783.

Chicago/Turabian Style

Nagae, Masamichi; Yamaguchi, Yoshiki. 2014. "Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions." Int. J. Mol. Sci. 15, no. 3: 3768-3783.


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