Int. J. Mol. Sci. 2014, 15(3), 3768-3783; doi:10.3390/ijms15033768

Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions

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Received: 26 December 2013; in revised form: 17 February 2014 / Accepted: 21 February 2014 / Published: 3 March 2014
(This article belongs to the Special Issue Glycosylation and Glycoproteins)
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Abstract: Linear polysaccharides are typically composed of repeating mono- or disaccharide units and are ubiquitous among living organisms. Polysaccharide diversity arises from chain-length variation, branching, and additional modifications. Structural diversity is associated with various physiological functions, which are often regulated by cognate polysaccharide-binding proteins. Proteins that interact with linear polysaccharides have been identified or developed, such as galectins and polysaccharide-specific antibodies, respectively. Currently, data is accumulating on the three-dimensional structure of polysaccharide-binding proteins. These proteins are classified into two types: exo-type and endo-type. The former group specifically interacts with the terminal units of polysaccharides, whereas the latter with internal units. In this review, we describe the structural aspects of exo-type and endo-type protein-polysaccharide interactions. Further, we discuss the structural basis for affinity and specificity enhancement in the face of inherently weak binding interactions.
Keywords: polysaccharide; lectin; 3D structure; polylactosamine; galectin; carbohydrate binding module; β-glucan; polysialic acid; antibody; affinity; hyaluronan; CD44
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MDPI and ACS Style

Nagae, M.; Yamaguchi, Y. Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions. Int. J. Mol. Sci. 2014, 15, 3768-3783.

AMA Style

Nagae M, Yamaguchi Y. Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions. International Journal of Molecular Sciences. 2014; 15(3):3768-3783.

Chicago/Turabian Style

Nagae, Masamichi; Yamaguchi, Yoshiki. 2014. "Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions." Int. J. Mol. Sci. 15, no. 3: 3768-3783.

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