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Int. J. Mol. Sci. 2014, 15(3), 3784-3798; doi:10.3390/ijms15033784
Article

Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain

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Received: 17 December 2013; in revised form: 20 February 2014 / Accepted: 21 February 2014 / Published: 3 March 2014
(This article belongs to the Special Issue Neuroprotective Strategies 2014)
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Abstract: Exposure to N-methyl-d-aspartate (NMDA) receptor antagonists has been demonstrated to induce neurodegeneration in newborn rats. However, in clinical practice the use of NMDA receptor antagonists as anesthetics and sedatives cannot always be avoided. The present study investigated the effect of the indirect cholinergic agonist physostigmine on neurotrophin expression and the extracellular matrix during NMDA receptor antagonist induced injury to the immature rat brain. The aim was to investigate matrix metalloproteinase (MMP)-2 activity, as well as expression of tissue inhibitor of metalloproteinase (TIMP)-2 and brain-derived neurotrophic factor (BDNF) after co-administration of the non-competitive NMDA receptor antagonist MK801 (dizocilpine) and the acetylcholinesterase (AChE) inhibitor physostigmine. The AChE inhibitor physostigmine ameliorated the MK801-induced reduction of BDNF mRNA and protein levels, reduced MK801-triggered MMP-2 activity and prevented decreased TIMP-2 mRNA expression. Our results indicate that AChE inhibition may prevent newborn rats from MK801-mediated brain damage by enhancing neurotrophin-associated signaling pathways and by modulating the extracellular matrix.
Keywords: developing brain; NMDA receptor; MK801; acetylcholinesterase; extracellular matrix; BDNF; neuroprotection developing brain; NMDA receptor; MK801; acetylcholinesterase; extracellular matrix; BDNF; neuroprotection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bendix, I.; Serdar, M.; Herz, J.; von Haefen, C.; Nasser, F.; Rohrer, B.; Endesfelder, S.; Felderhoff-Mueser, U.; Spies, C.D.; Sifringer, M. Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain. Int. J. Mol. Sci. 2014, 15, 3784-3798.

AMA Style

Bendix I, Serdar M, Herz J, von Haefen C, Nasser F, Rohrer B, Endesfelder S, Felderhoff-Mueser U, Spies CD, Sifringer M. Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain. International Journal of Molecular Sciences. 2014; 15(3):3784-3798.

Chicago/Turabian Style

Bendix, Ivo; Serdar, Meray; Herz, Josephine; von Haefen, Clarissa; Nasser, Fatme; Rohrer, Benjamin; Endesfelder, Stefanie; Felderhoff-Mueser, Ursula; Spies, Claudia D.; Sifringer, Marco. 2014. "Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain." Int. J. Mol. Sci. 15, no. 3: 3784-3798.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert