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Int. J. Mol. Sci. 2014, 15(2), 2840-2857; doi:10.3390/ijms15022840
Review

Gram-Negative Flagella Glycosylation

*  and
Department of Microbiology, Faculty of Biology, University of Barcelona, Diagonal 643, Barcelona 08071, Spain
* Author to whom correspondence should be addressed.
Received: 4 January 2014 / Revised: 20 January 2014 / Accepted: 27 January 2014 / Published: 19 February 2014
(This article belongs to the Special Issue Glycosylation and Glycoproteins)
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Abstract

Protein glycosylation had been considered as an eccentricity of a few bacteria. However, through advances in analytical methods and genome sequencing, it is now established that bacteria possess both N-linked and O-linked glycosylation pathways. Both glycosylation pathways can modify multiple proteins, flagellins from Archaea and Eubacteria being one of these. Flagella O-glycosylation has been demonstrated in many polar flagellins from Gram-negative bacteria and in only the Gram-positive genera Clostridium and Listeria. Furthermore, O-glycosylation has also been demonstrated in a limited number of lateral flagellins. In this work, we revised the current advances in flagellar glycosylation from Gram-negative bacteria, focusing on the structural diversity of glycans, the O-linked pathway and the biological function of flagella glycosylation.
Keywords: flagella; Gram-negative; glycosylation flagella; Gram-negative; glycosylation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Merino, S.; Tomás, J.M. Gram-Negative Flagella Glycosylation. Int. J. Mol. Sci. 2014, 15, 2840-2857.

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